Immunoregulatory Networks

描述(由申请人提供)：本提案请求支持由Dario A.A.Vignali、Steven F.Ziegler和Hilde Cheroutre组织的题为免疫监管网络的Keystone研讨会，该会议将于2011年4月1日至6日在科罗拉多州布雷肯里奇举行。免疫调节网络在预防自身免疫和其他炎症性疾病方面发挥着关键作用，但也限制了抗肿瘤免疫，调节了对病原体的免疫反应。虽然调节性T细胞(Treg)是这个网络的中心组成部分，但还有许多其他细胞群体和分子途径对这些网络做出贡献。关于免疫调节网络的Keystone研讨会会议将重点讨论不同的细胞和分子成分如何整合和合作，以防止自身免疫和控制炎症免疫反应。这次会议将剖析我们目前对四个关键领域的理解：调控细胞发育和稳态的转录控制，免疫调控网络的分子调控，调控功能的机制，以及调控T细胞的可塑性。我们还旨在讨论Treg如何与不同类型的细胞相互作用，或者利用不同的细胞因子来调节或间接调节它们的活动。最后，我们将评估如何利用所取得的进展来开发治疗自身免疫性疾病、炎症性疾病、慢性感染和癌症的新疗法。 与公共卫生相关：免疫系统是分子和细胞的复杂集合体，它们同步工作，微调对病原体的反应，并调节疾病状态。这些基本的生物学过程是由“免疫调节网络”调节的，这是一个同样复杂的相互作用、相互制衡的网络。关于免疫调节网络的Keystone研讨会会议将重点讨论不同的细胞和分子成分如何整合和合作，以防止自身免疫和控制炎症免疫反应。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunoregulatory Networks, organized by Dario A.A. Vignali, Steven F. Ziegler and Hilde Cheroutre, which will be held in Breckenridge, Colorado from April 1 - 6, 2011. Immunoregulatory networks play a pivotal role in preventing autoimmunity and other inflammatory diseases, but also restrict anti-tumor immunity and modulate immune responses to pathogens. While regulatory T cells (Tregs) are a central component of this network, there are many other cell populations and molecular pathways that contribute to these networks. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses. This meeting will dissect our current understanding of four key areas: transcriptional control of regulatory cell development and homeostasis, molecular control of immunoregulatory networks, mechanisms of regulatory function, and regulatory T cell plasticity. We also aim to discuss how Tregs interact with different cell types or utilize different cytokines that modulate or indirectly mediate their activity. Finally, we will assess how the advances presented can be utilized to develop novel therapies for autoimmune diseases, inflammatory diseases, chronic infections and cancers. PUBLIC HEALTH RELEVANCE: The immune system is a complex conglomeration of molecules and cells that work synchronously to fine tune responses to pathogens and modulate disease states. These fundamental biological processes are mediated by "immunoregulatory networks", an equally complex network of interactions, checks and balances. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses.