Research Training - Genetics of Substance Abuse

描述(由申请人提供)：这项提案正在寻求通过机构培训赠款为博士后和博士后研究员提供培训计划的持续支持，这些博士后研究员将从事专注于研究基因对药物滥用的影响的研究生涯。IBG的教职员工是杰出的和活跃的研究，IBG的科学家40多年来一直积极开展对药物滥用的遗传影响的研究。与药物滥用有关的重大研究项目目前正在人类和动物行为遗传学方面进行。生物计量学、统计学和数量遗传学技术的应用以及数量性状基因座方法的发展使控制复杂性状的基因得以定位和鉴定。来自这种分析的信息，以及神经化学、神经药理学、神经生理学和分子遗传学研究，将提供对与行为相关的基因功能的理解。人类和动物行为遗传学的主要研究项目目前都在进行中，包括大规模的国家合作研究，积累了可用于药物滥用研究的DNA储存库和丰富的表型数据集。可用于基因分析的设备，包括全基因组分析、基因功能和表达研究，以及行为、生化和神经生理学研究。请拨资金支持4名博士后和2名博士后实习生，为期5年。博士前实习生获得合作学术单位的博士学位和行为遗传学认证。培训计划的学术要求包括行为遗传学、定量和生物测定遗传学、理论和基于计算机的统计学、分子遗传学、生物信息学和基因组学、负责任的研究行为以及行为和临床表型课程的培训。根据学位授予学术单位的不同，附加要求也有所不同。研究经验是培训不可或缺的一部分。博士后实习生还会攻读正规的课程，强调个人研究以及分子和数量行为遗传学方面的能力。为心理健康研究职业生涯做准备的其他活动包括：指导学生和/或技术人员、主持研讨会演讲者、客座演讲、每周一次的期刊俱乐部，以及强制参加关于负责任的研究行为的课程。这项建议是为了培训科学家，他们将能够为我们理解遗传因素对药物滥用的易感性做出重大贡献。这一认识将导致预防和减轻药物滥用的新办法。

DESCRIPTION (provided by applicant): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.