SCOR ON LOWER URINARY TRACT FUNCTION IN WOMEN

建议更新加州大学旧金山分校关于女性下尿路功能的SCOR是一个特殊的机会，可以继续保持这一独特而富有成效的翻译中心。加州大学旧金山分校2002-2007年度SCOR通过提高基础和临床研究人员的工作效率，实现了我们创新翻译研究的首要目标，发表了41篇手稿，并通过一项U01、四项R01和一项NIH荣誉奖给予支持。通过催化女性下尿路功能的“知识合成”，我们的研究项目正在积极地为改善患者护理做出贡献。对于我们的SCOR续签，我们将建立在强大的领导力和来自多个学科的资深科学家的基础上，并拥有越来越多的资金和成功的研究项目。加州大学旧金山分校SCOR的最大优势包括国际公认的实验室和临床研究人员的密切联系、我们当前SCOR项目的富有成效的成果以及有效的翻译研究合作。 加州大学旧金山分校的SCOR多学科、多机构方案提出了三个新项目，以及继续和扩大生物统计和数据管理与行政核心，科学整合和合作的四个主要领域包括： 1.发展治疗压力性尿失禁的新疗法：鉴定脂肪来源的干细胞用于治疗； 2.确定肥胖、糖尿病前期和糖尿病导致大小便失禁的机制：在现实的2型糖尿病大鼠模型和基于种族多样性的预期人群队列中； 3.探索大小便失禁的遗传危险因素：利用我们基于群体的DNA文库和基因在独特的大小便失禁大鼠模型中的表达； 4.了解激素和选择性雌激素受体调节剂对大小便失禁的影响：包括基本机制研究和与药学记录的联系以及植物雌激素的使用 为了实现我们对女性下尿路的创新转化研究的总体目标，加州大学旧金山分校的SCOR拥有强大的机构支持、与加州大学旧金山分校的资深科学家和其他国际公认的研究人员的合作、杰出的领导力以及一支具有出色工作效率记录的高级和初级调查人员队伍。加州大学旧金山分校的SCOR将继续加快基础科学发现为我们的患者和人群的健康服务的步伐。

The proposed renewal of the UCSF SCOR on Lower Urinary Tract Function in Women is an exceptional opportunity to continue the unique and productive translational center. The UCSF SCOR 2002-2007 achieved our overriding goal of innovative translational research by enhancing the productivity of our basic and clinical investigators resulting in 41 published manuscripts and grant support through a U01, four R01s, and a NIH Merit award. Catalyzing "Knowledge Synthesis" on lower urinary tract function in women, our research programs are actively contributing to improved patient care. For our SCOR renewal, we are building on strong leadership and senior scientists from many disciplines with a growing foundation of funded, successful research programs. The greatest strengths of our UCSF SCOR include the close proximity of internationally recognized laboratory and clinical researchers, the productive achievements of our current SCOR projects and effective translational research collaborations. The UCSF SCOR multidisciplinary, multi-institutional program proposes three new projects and continuation and expansion of the Biostatistics and Data Management and Administrative Cores, The 4 major areas of scientific integration and collaboration include: 1. Advancing novel treatments for stress incontinence: Characterizing adipose-derived stem cells for treatment; 2. Identifying mechanisms by which obesity, pre-diabetes, and diabetes cause incontinence: In a realistic type 2 diabetes rat model and prospective population-based ethnically diverse cohorts; 3. Exploring genetic risk factors for incontinence: Using our population-based DNA bank and gene expression in a unique incontinent rat model; 4. Understanding the effects of hormones and selective estrogen receptor modulators on incontinence: Including basic mechanism investigations and linkage to pharmacy records and use of phytoestrogens To achieve our overall goal of innovative translational research on the female lower urinary tract, the UCSF SCOR has strong institutional support, collaborations with UCSF senior scientists and other internationally recognized researchers, outstanding leadership and a cadre of senior and junior investigators with a record of excellent productivity. The UCSF SCOR will continue to accelerate the pace at which discoveries in basic science can serve the health of our patients and populations.