Cytokine JAK-STAT Signaling in Immunity and Disease

 描述(由申请人提供)：请求支持由Curt M.Horvath、John J.O‘Shea和Stephanie S.Watowich组织的题为细胞因子JAK-STAT免疫和疾病信号传递的Keystone研讨会。会议将于2016年1月10日至15日在科罗拉多州的斯普林斯举行。细胞因子是重要的细胞外因子，在正常生理和疾病中指导各种生物反应。细胞因子信号在很大程度上是通过四个Janus激酶(JAK)蛋白和七个信号转导和转录激活蛋白(STAT)介导的，这些分子与广泛的额外细胞内信号相互作用，推动基因表达的全球显著变化。细胞因子JAK-STAT通路与先天免疫和获得性免疫、炎症、干细胞和发育生物学以及癌症生物学的各个方面密切相关。由于JAK-STAT通路产生对广泛的生物现象至关重要的共同和独特的表型，对这些信号转导级联如何调节、功能以及与额外的细胞反应整合的基本理解随着一般和通路特异性机制的发现而不断得到完善。此外，药物发现工作已经产生了针对JAK和STATS的小分子，这些小分子在炎症、关节炎和各种癌症的临床治疗中很有希望。这次会议恰逢JAK-STAT信号发现25周年，将邀请对相关学科做出重大贡献的演讲者与该领域的细胞因子JAK-STAT老手和新手结对，并有大量机会从提交的摘要中挑选简短的演讲。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Cytokine JAK-STAT Signaling in Immunity and Disease, organized by Curt M. Horvath, John J. O'Shea and Stephanie S. Watowich. The meeting will be held in Steamboat Springs, Colorado from January 10-15, 2016. Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with both cytokine JAK-STAT veterans and newcomers to the field, with ample opportunities for short talks selected from submitted abstracts.