The role of the Ras signalling molecule, C3G, in the interaction of neural precursor cells and their environment

大脑发育障碍影响1-3%的人口。精神发育迟滞疾病谱包括神经元迁移障碍和神经前体增殖障碍。我们建议研究调节神经元迁移、存活和增殖的分子机制。我们已经鉴定了一种蛋白质C3 G，它对神经系统发育的三个方面至关重要：（A）C3 G限制神经前体细胞增殖。(B)C3 G对神经元的存活至关重要。(C)C3 G对神经元迁移至关重要。C3 G在蛋白质级联中起作用，称为Ras信号通路，其将信号从细胞外环境传递到细胞核中，以引起细胞对来自外部的提示的适当反应。我们将鉴定与C3 G一起影响神经前体增殖、神经元存活和迁移的重要过程的蛋白质。该项目将充分揭示对正常智力发展至关重要的细胞过程的关键调节机制。

Developmental brain disorders affect 1-3% of the population. The mental retardation disease spectrum includes neuronal migration disorders and neural precursor proliferation disorders. We propose to study a molecular mechanism regulating neuronal migration, survival and proliferation. We have identified a protein, C3G, which is essential for three aspects of nervous system development: (A) C3G limits neural precursor cell proliferation. (B) C3G is essential for neuronal survival. (C) C3G is crucial for neuronal migration. C3G acts in a cascade of proteins, known as the Ras signalling pathway, which transmits signals from the extracellular environment into the cell nucleus to elicit appropriate responses of the cell to cues from the outside. We will identify proteins that, together with C3G, affect the important processes of neural precursor proliferation, and neuron survival and migration. This project will fully characterise a key regulatory mechanism of cellular processes crucial to the development of normal intelligence.