Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network
Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network
批准号:
nhmrc : 1058769
负责人:
A/Pr Brett Collins
金额:
$37.29万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
神经元的通讯依赖于胞吐作用,神经元通过胞吐作用释放神经递质。胞吐作用支持诸如最简单的肌肉运动到复杂任务(如学习和记忆)的过程,并且在几种神经退行性病变中改变。我们将研究肌球蛋白-6如何控制胞吐作用。这项研究对于理解神经元在健康和疾病中如何交流非常重要,并且与糖尿病中的胰岛素释放等其他过程相关。
英文摘要
Neuronal communication relies on the process of exocytosis by which neurons release a neurotransmitter. Exocytosis underpins processes such as the simplest muscle movement to complex tasks such as learning and memory, and is altered in several neurodegenerative pathologies. We will investigate how the protein Myosin-6 controls exocytosis. This research will be important for understanding how neurons communicate in health and disease and will be relevant to other processes such as insulin release in diabetes.
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会议论文
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : GNT1136021
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项目类别:Research Fellowships
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资助金额:$64.02万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : 1138452
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项目类别:Project Grants
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资助金额:$37.1万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : GNT1138452
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项目类别:Project Grants
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资助金额:$54.87万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : GNT1139316
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项目类别:Project Grants
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资助金额:$62.0万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : GNT1138083
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项目类别:Project Grants
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资助金额:$65.44万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : 1136021
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项目类别:Research Fellowships
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资助金额:$43.29万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : 1138083
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项目类别:Project Grants
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资助金额:$44.25万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : 1139316
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项目类别:Project Grants
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资助金额:$41.92万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : GNT1099114
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项目类别:Project Grants
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资助金额:$63.2万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : 1099114
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项目类别:Project Grants
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资助金额:$43.34万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : GNT1080995
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项目类别:Project Grants
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资助金额:$65.35万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : 1080995
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项目类别:Project Grants
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资助金额:$44.98万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : GNT1061574
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项目类别:Career Development Fellowships
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资助金额:$44.78万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : 1061574
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项目类别:Career Development Fellowships
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资助金额:$31.28万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Endosomal sorting of amyloid precursor protein in Alzheimer's disease
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批准号:nhmrc : 1058734
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项目类别:Project Grants
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资助金额:$57.25万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Unravelling Munc18 dual function in exocytosis
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批准号:nhmrc : 1044014
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项目类别:Project Grants
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资助金额:$34.4万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
Understanding how membrane trafficking controls the levels of Alzheimer's disease causing A? peptides
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批准号:nhmrc : 1042082
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项目类别:Project Grants
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资助金额:$31.93万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
The role of intracellular protein trafficking in Alzheimer's disease
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批准号:nhmrc : 1025538
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项目类别:Project Grants
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资助金额:$0.0万
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财政年份:2012
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负责人:A/Pr Brett Collins
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依托单位:
Control of neurosecretion by Munc18
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批准号:nhmrc : 631349
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项目类别:NHMRC Project Grants
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资助金额:$32.85万
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财政年份:2010
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负责人:A/Pr Brett Collins
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依托单位:
Retromer based Endosome Trafficking
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批准号:nhmrc : 511072
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项目类别:NHMRC Project Grants
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资助金额:$32.72万
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财政年份:2008
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负责人:A/Pr Brett Collins
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依托单位:
海外基金