Using single-cell genomics to resolve functional diversification by CD4+ T cells in vivo

在免疫反应过程中，单个CD4+ T细胞繁殖并产生数百个后代，而家庭中的近亲往往会发展出截然不同的技能。这种差异是如何从一个祖先中产生的尚不清楚。我们使用新方法以前所未有的细节观察单个CD4+ T细胞，使我们能够看到近亲是如何开始分开生长的。利用这一点，我们希望找到新的方法来教育CD4+ T细胞来预防传染性和免疫介导的疾病。

During immune responses, individual CD4+ T cells multiply and produce hundreds of descendants, with close relatives within a family often developing very different skills. How such differences emerge from one ancestor remains unclear. We use new methods to look at individual CD4+ T cells in unprecedented detail, allowing us to see how close relatives begin to grow apart. Using this, we hope to find novel ways of educating CD4+ T cells to prevent infectious and immune-mediated diseases.