Critical upgrade of 600 MHz NMR Spectrometer

该设备应用寻求对急需的附件的支持，以使最先进的高场核磁共振（NMR）光谱不仅用作结构表征的仪器，而且还用作研究反应途径的强大工具。配备了全新的布鲁克TBO 600 MHz三通道宽带Smartprobe，以及升级的放大器、控制台和数据采集系统，我们的600 MHz光谱仪将成为一台功能强大、高灵敏度的仪器，在滑铁卢大学的NMR设施中具有无与伦比的分辨率。这种升级后的仪器将提供一套实验，如1D和2D 19F（去）耦合实验，这些实验对科学与工程学院，药学院和滑铁卢纳米技术研究所的许多新员工的研究计划至关重要。这些能力目前在滑铁卢是不可用的，它们对于使我们的HQP能够高效和快速地阐明新有机化合物的结构至关重要，对于我们通过NMR光谱研究反应机理的能力至关重要。 所要求的TBO探头，以及将其与当前600 MHz NMR光谱仪集成所需的相关系统硬件，放大器和数据采集系统，将减轻我们校园内唯一的500 MHz仪器目前存在的高场NMR的巨大用户积压。这些也将大大改善和简化我们的HQP用于新材料结构解析的技术，提供目前在我们现有的任何NMR光谱仪上都无法获得的新实验。升级后的NMR将满足来自化学，生物化学，生物学和化学工程以及药学院和滑铁卢纳米技术研究所的34个当地研究小组的研究需求。 该请求是迫切需要的持续生存和多样化的合成研究的增长正在UWaterloo进行的100多个当前的HQP在新材料合成，药物化学，生物化学，有机化学和化学工程和纳米技术领域，其中大多数人依赖于高场NMR为他们的论文项目。

This equipment application seeks the support for the critically needed accessories to enable state-of-the-art high field nuclear magnetic resonance (NMR) spectroscopy to be used not only as an instrument for structural characterization, but also a powerful tool for investigating reaction pathways. Equipped with a new Bruker TBO 600 MHz three channel broad band Smartprobe, and with upgraded amplifiers, console boards and data acquisition systems, our 600 MHz spectrometer with be a powerful, highly sensitive machine with unmatched resolution within the NMR facility at UWaterloo. This upgraded instrument will provide a suite of experiments, such as 1D- and 2D 19F (de)coupled experiments that are crucial to the research programs of many new hires within the Faculties of Science and Engineering, the School of Pharmacy and the Waterloo Institute for Nanotechnology. These capabilities are currently unavailable at Waterloo, and they are critical to enabling our HQP to elucidate structures of new organic compounds with high efficacy and speed, and critical to our ability to investigate reaction mechanisms by NMR spectroscopy. The requested TBO probe, and the associated system hardware, amplifiers and data acquisition systems required to integrate it with the current 600 MHz NMR spectrometer, will relieve the huge user backlog for high field NMR that currently exists for our sole 500 MHz instrument on campus. These will also greatly improve and simplify the techniques used by our HQP for structural elucidation of new materials by providing new experiments that are currently unavailable on any of our existing NMR spectrometers. The upgraded NMR will serve the research needs of 34 local research groups from Chemistry, Biochemistry, Biology and Chemical Engineering, and from the School of Pharmacy and the Waterloo Institute for Nanotechnology. The request is critically needed for the continued survival and growth of the diverse synthetic research being conducted at UWaterloo by over 100 current HQP in the field of new materials synthesis, medicinal chemistry, biological chemistry, organic chemistry and chemical engineering and nanotechnology, most of whom depend on high field NMR for their thesis projects.