New Reactions and Strategies in Synthesis

这项研究的重点是开发新的有机合成方法，并将其应用于复杂天然产物的合成。建议的研究包括开发构造性合成烯烃的方法，开发以硅烷化对甲苯肼为亲电体的新的烷基化策略，以及开发以伪麻黄碱的α，β-不饱和酰胺作为手性Michael受体的不对称Michael加成反应的新方法。感兴趣的目标包括双环戊二烯、L-696,474和特拉帕斯汀。有机化学和高分子化学项目支持哈佛大学化学和化学生物学系的安德鲁·G·迈尔斯博士的研究。迈尔斯教授将把他的工作重点放在合成方法学的开发和具有重要生物学特性的天然产物的制备上。这项研究将对制药行业产生广泛的影响，是培养研究生的极好工具。

The focus of this research is the development of new methods for organic synthesis and the application of the resulting methodology to the synthesis of complex natural products. Studies proposed include the development of methods for the constructive synthesis of alkenes, the development of new strategies for alkylation using silylated tosylhydrazones as electrophiles and the development of new methodology for asymmetric Michael addition reactions using alpha, beta-unsaturated amides of pseudoephedrine as chiral Michael acceptors. Targets of interest include bicyclopentadienylene, L-696,474 and terpestacin. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Andrew G. Myers of the Department of Chemistry and Chemical Biology at Harvard University. Professor Myers will focus his work on the development of synthetic methodology and the preparation of natural products having important biological properties. The research will have a broad impact on the pharmaceutical industry and is an excellent vehicle for the training of graduate students.