p53 family : function and cancer therapy

p53 家族：功能和癌症治疗

• 批准号: 17013072
• 负责人: TOKINO Takashi
• 金额: $ 30.08万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013072/
• 关键词: 癌; 癌抑制遺伝子; 遺伝子治療; p53; p63; p73; アポトーシス; ウイルスベクター; がん; がん抑制遺伝子; がん治療

Our in silico approach is powerful for identification of p53 target genes and for further understanding the function of p53 in tumorigenesis. We identified that PEDF, FLOT2, and APOD are direct transcriptional targets of the p53 family member genes. We found that significant antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines in a mouse model. Furthermore, the histone deacetylase inhibitor FK228 was found to enhance adenovirus-mediated p53 family gene therapy in cancer models.

我们的计算机模拟方法对于鉴定p53靶基因和进一步理解p53在肿瘤发生中的功能是强大的。我们确定PEDF、FLOT2和APOD是p53家族成员基因的直接转录靶点。我们发现腺病毒介导的p53家族基因转移对小鼠骨肉瘤细胞系有显著的抗肿瘤作用。此外，组蛋白去乙酰化酶抑制剂FK228被发现在癌症模型中增强腺病毒介导的p53家族基因治疗。

项目成果

Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.

无基因突变口腔癌β-连环蛋白表达异常：与细胞周期蛋白D1和表皮生长因子受体表达、Ki-67标记指数及临床病理特征的相关性。

• 发表时间: 2005
• 期刊: H u m P a t h o l 36(3)
• 作者: Odajima T;Sasaki Y;Tanaka N;Kato-Mori Y;Asanuma H;Ikeda T;Satoh M;Hiratsuka H;Tokino T;Sawada N
• 通讯作者: Sawada N

Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.

通过 CHFR 基因表达缺失而过度表达 Aurora A 可通过增强 NF-kappaB 活性来增加 HTLV-1 感染的 T 细胞的生长和存活。

• 发表时间: 2009
• 期刊: Int J Cancer 124(11)
• 作者: Tomita M;Toyota M;Ishikawa C;Nakazato T;Okudaira T;Matsuda T;Uchihara JN;Taira N;Ohshiro K;Senba M;Tanaka Y;Ohshima K;Saya H;Tokino T;Mori N
• 通讯作者: Mori N

LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis.

在幽门螺杆菌相关的肥大性胃炎中，LINE-1 低甲基化与 CpG 岛甲基化增加相关。

• 发表时间: 2008
• 期刊: C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10)
• 作者: Yamamoto E;Toyota M;Suzuki H;Kondo Y;Sanomura T;Murayama Y;Ohe-Toyota M;Muruyama R;Nojima M;Ashisa M;Fujii K;Sasaki Y;Hayashi N;Mori M;Imai K;Tokino T;Shinomura Y
• 通讯作者: Shinomura Y

Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is enieenetically silenced in gastric cancer

细胞质 RASSF2A 是一种促凋亡介质，其表达在胃癌中被普遍沉默

• 发表时间: 2008
• 期刊: Carcinogenesis 29
• 作者: Maruyama R;et.al.
• 通讯作者: et.al.

Epigenetic inactivation of the candidate tumor suppressor gene HOXB 13 in human renal cell carcinama.

人肾细胞癌中候选抑癌基因 HOXB 13 的表观遗传失活。

• 发表时间: 2006
• 期刊: Oncogene 25・12
• 作者: T. Mishiro;et.al.;R.Maruyama;M.Kusano;K.Terasawa;H.Okuda
• 通讯作者: H.Okuda