Elucidation of molecular basis and therapeutic strategy of immune-mediated neurological diseases based on comprehensive analysis of autoantibodies

基于自身抗体综合分析阐明免疫介导的神经系统疾病的分子基础和治疗策略

• 批准号: 23249048
• 负责人: TSUJI Shoji
• 金额: $ 30.78万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23249048/
• 关键词: 神経病態免疫学; プロテインアレイ; 免疫性神経疾患; 自己抗体; プロファイリング; 傍腫瘍性症候群

Employing active protein arrays containing recombinant proteins with preserved native structures, sera from 20 patients with paraneoplastic cerebellar degeneration, immune-mediated encephalitis, acute autonomic neuronopathy, and immune-mediated myosisit are subjected to comprehensive antigen screening. Forty to 60 antigens were recognized by the individual serum. Search for homologous regions among the antigens recognized by the same serum revealed that the eiptopes are not shared among these antigens.

采用含有保留天然结构的重组蛋白的活性蛋白阵列，对20例副肿瘤性小脑变性、免疫介导的脑炎、急性自主神经元病和免疫介导的肌炎患者的血清进行全面的抗原筛选。个体血清可识别40 ~ 60种抗原。在同一血清识别的抗原之间寻找同源区域，发现这些抗原之间不共享表位。

项目成果

Anti-NMDA Receptor Encephalitis Associated With Transient Cerebral Dyschromatopsia

与短暂性脑色盲相关的抗 NMDA 受体脑炎

• 发表时间: 2014
• 期刊: Prosopagnosia, and Lack of Stereopsis. J. Neuro-ophthalmol
• 作者: Sawamura H;Yamamoto T;Ohtomo R;Bannai T;Wakakura M;Tsuji S
• 通讯作者: Tsuji S

Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy

• DOI: 10.1016/j.jneuroim.2011.08.016
• 发表时间: 2011-10-28
• 期刊: JOURNAL OF NEUROIMMUNOLOGY
• 影响因子: 3.3
• 作者: Kuwahara, Motoi;Suzuki, Seiko;Kusunoki, Susumu
• 通讯作者: Kusunoki, Susumu

Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type

与抗肌酸激酶（脑型）肿瘤神经抗体相关的副肿瘤性小脑变性

• DOI: 10.1016/j.jns.2013.08.022
• 发表时间: 2013
• 期刊: J Neurol Sci
• 影响因子: 4.4
• 作者: Tetsuka;S. Tominaga;K. Ohta;E. Kuroiwa;K. Sakashita;E. Kasashima;K. Hamamoto;T. Namekawa;M. Morita;M. Natsui;S. Morita;T. Tanaka;K. Takiyama;Y. Nakano;I. Endo;H.
• 通讯作者: H.

Aberrant expression of myogenin in inclusion body myositis: Immunohistochemical studies of transcription factors regulating myogenesis in inflammatory myopathies.

包涵体肌炎中肌生成素的异常表达：炎症性肌病中调节肌生成的转录因子的免疫组织化学研究。

• DOI: 10.1111/cen3.12000
• 发表时间: 2012
• 期刊: Clin Exp Neuroimmunol
• 作者: Kubota A;Shimizu J;Iwata A;Tsuji S.
• 通讯作者: Tsuji S.

Integrated view of the human chromosome X-centric proteome project.

人类 X 染色体中心蛋白质组项目的综合视图。

• DOI: 10.1021/pr300844p
• 发表时间: 2013
• 期刊: J Proteome Res.
• 作者: Yamamoto T;Nakayama K;Hirano H;Tomonaga T;Ishihama Y;Yamada T;Kondo T,Kodera Y;Sato Y;Araki N;Mamitsuka H;Goshima N.
• 通讯作者: Goshima N.