Applied Genomics

应用基因组学

• 批准号: 16065101
• 负责人: TSUJI Shoji
• 金额: $ 148.67万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16065101/
• 关键词: 疾患関連遺伝子; ゲノムワイド関連解析; ヒトゲノム配列再解析; メディカルインフォマティクス; 微生物ゲノム; 産業微生物ゲノム; ゲノム; 遺伝子; 臨床; 微生物; 社会医学; 分子遺伝学; 多型解析; 有用微生物; 病原微生物; ゲノムインフォーマティック; 生命倫理; 遺伝医学; ゲノムインフォーマティックス

This study has focused on application of genome-based studies for better understanding the molecular mechanisms of diseases, for better understanding mechanisms of production of substances useful for human life by microorganisms, and for better understanding the molecular basis of pathogenecity of virulent microorganisms. This study has also focused on various issues arising between the genome research and the society. In the study for better understanding the molecular mechanisms of diseases, we have identified causative genes for various diseases including erebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL),Costello syndrome,and cardio-facio-cutaneous (CFC) syndrome. For polygenic diseases, we have identified disease-susceptibility genes for a number of diseases including diabetes mellitus, cerebral aneurysms, rheumatoid arthritis and Parkinson disease. In the research focusing on production of useful substances by microorganisms, we have elucidated the molecular basis for production of substances for human life based on the genome structures of Aspergillus oryzae and Actinomyces. With regard to the molecular basis of virulent microorganisms, we have elucidated molecular basis of virulence of O157 (Enterohemorrhagic Escherichia coli). In the research field of society-genome interactions, we have focused on science communication of genome research activities. We have also put our effort to encourage collection of genomic resources by introducing the education and certification systems for genome medical research coordinators.

为了更好地了解疾病的分子机制，更好地了解微生物产生有益于人类生活的物质的机制，以及更好地了解强毒微生物致病的分子基础，本研究集中在基于基因组的研究的应用上。这项研究还关注了基因组研究与社会之间出现的各种问题。在这项研究中，为了更好地了解疾病的分子机制，我们已经确定了各种疾病的致病基因，包括伴有皮质下梗塞和白质脑病的常染色体隐性动脉病(CARASIL)、Costello综合征和心面部皮肤综合征(CFC)综合征。对于多基因疾病，我们已经确定了一些疾病的易感基因，包括糖尿病、脑动脉瘤、类风湿性关节炎和帕金森病。在微生物产生有用物质的研究中，我们以米曲霉和放线菌的基因组结构为基础，阐明了产生人类生活物质的分子基础。在毒力微生物的分子基础方面，我们阐明了O157(肠出血性大肠杆菌)毒力的分子基础。在社会-基因组相互作用的研究领域，我们一直专注于基因组研究活动的科学传播。我们还通过引入基因组医学研究协调员的教育和认证制度，努力鼓励基因组资源的收集。

项目成果

Interference of CREB dependent transcriptional activation expanded opolyglutamine stretches- Aumentation of transcriptional activation as a potential therapeutic strategy for polyglutarnine diseases/

CREB依赖性转录激活的干扰扩展了多聚谷氨酰胺延伸-增强转录激活作为多聚谷氨酰胺疾病的潜在治疗策略/

• 发表时间: 2005
• 期刊: J.Neurochem 93
• 作者: Shimohata;M;Shimohata;T,.Igarashi;S;Naruse;S;Tsujil;S.
• 通讯作者: S.

Appropriate data cleaning methods for genome-wide association study

• DOI: 10.1007/s10038-008-0322-y
• 发表时间: 2008-10-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Miyagawa, Taku;Nishida, Nao;Tokunaga, Katsushi
• 通讯作者: Tokunaga, Katsushi

DataBase of Human Transcription Start Sirtes, progress report 2006.

人类转录数据库启动 Sirtes，2006 年进度报告。

• 发表时间: 2006
• 期刊: Nucleic Acids Res 34
• 作者: Yamashita;R.;Suzuki;Y.;Wakaguri;H.;Tsuritani;K.;Nakai;K.;Sugano;S.
• 通讯作者: S.

Development of high-throughput microarray-based resequencing system for neurological disorders and its app-lication to molecular genetics of amyotrophic lateral sclerosis

基于高通量微阵列的神经系统疾病重测序系统的开发及其在肌萎缩侧索硬化症分子遗传学中的应用

• 发表时间: 2008
• 期刊: Archives of Neurology
• 作者: 347. Takahashi;Y;Seki;N;Ishiura;H;Mitsui;J;Matsukawa;T;Kishino;A;Onodera;O;Aoki;M;Shimozawa;M;Murayama;S;Itoyama;Y;Suzuki;Y;Sobue;S;Nishizawa;M;Goto;J
• 通讯作者: J

Familial Ischemic Cerebral Small-Vessel Disease, Alopecia, and Spondylosis Caused by Mutations in the HTRA1 Gene

HTRA1 基因突变引起的家族性缺血性脑小血管病、脱发和脊椎病

• 发表时间: 2009
• 期刊: New Engl J Med 360
• 作者: Hara K;Shiga A;Fukutake T;Nozaki H;Miyashita A;Yokoseki A;Kawata H;Koyama A;Arima K;Takahashi T;Ikeda M;Shiota H;Tamura M;Shimoe Y;Hirayama M;Arisato T;Yanagawa S;Tanaka A;Nakano I;Ikeda S;Yoshida Y;Yamamoto T;Ikeuchi T;Kuwano R;Ni
• 通讯作者: Ni