Applied Genomics

点击翻译按钮获取中文摘要

This study has focused on application of genome-based studies for better understanding the molecular mechanisms of diseases, for better understanding mechanisms of production of substances useful for human life by microorganisms, and for better understanding the molecular basis of pathogenecity of virulent microorganisms. This study has also focused on various issues arising between the genome research and the society. In the study for better understanding the molecular mechanisms of diseases, we have identified causative genes for various diseases including erebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL),Costello syndrome,and cardio-facio-cutaneous (CFC) syndrome. For polygenic diseases, we have identified disease-susceptibility genes for a number of diseases including diabetes mellitus, cerebral aneurysms, rheumatoid arthritis and Parkinson disease. In the research focusing on production of useful substances by microorganisms, we have elucidated the molecular basis for production of substances for human life based on the genome structures of Aspergillus oryzae and Actinomyces. With regard to the molecular basis of virulent microorganisms, we have elucidated molecular basis of virulence of O157 (Enterohemorrhagic Escherichia coli). In the research field of society-genome interactions, we have focused on science communication of genome research activities. We have also put our effort to encourage collection of genomic resources by introducing the education and certification systems for genome medical research coordinators.