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Characteristics and control of the upper airway remodeling

上气道重塑的特点和控制

基本信息

批准号：
18591864
负责人：
TAKEUCHI Kazuhiko
金额：
$ 2.36万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The mechanisms by which nasal mucosa remodeling occurs in allergic rhinitis have remained unclear. The aim of this study was to establish a guinea pig model of allergic rhinitis with remodeling and to examine the effects of dexamethasone and pranlukast on nasal mucosa remodeling. Three groups of ovalbumin-sensitized Hartley guinea pigs received daily intranasal challenges with ovalbumin for 1, 8, 12 weeks, respectivelylb examine the effect of dexamethasone and pranlukast, the animals were divided into 4 groups : negative control group ; ovalbumin-sensitized group ; ovalbumin+dexamethasone gmup ; and ovalbumin+pranlukast group. During 12 weeks of intranasal exposure to ovalbumin, the latter two groups received daily intraperitoneal injections of dexamethasone and pranlukast, respectively. Prolonged ovalbumin challenge caused significant pathological changes in the nasal mucosa and conchae, including eosinophil infiltration, significant goblet cell hyperplasia, epithelial damage and deposition of extracellular matrix. In contrast to the negative control group, the ovalbumin-sensitized group exhibited significant goblet cell hyperplasia, epithelial damage and deposition of extracellular matrix. These changes were significantly inhibited by dexamethasone and pranlukast, respectively. We have established a model of upper airway remodeling in guinea pigs. The tissue remodeling was inhibited by early intervention with the and allergic-inflammatory agents dexamethasone and pranlukast

变应性鼻炎鼻粘膜重塑的机制尚不清楚。本研究旨在建立豚鼠变应性鼻炎鼻黏膜重塑模型，观察地塞米松和普仑司特钠对鼻黏膜重塑的影响。将卵白蛋白致敏的Hartley豚鼠分为阴性对照组、卵白蛋白致敏组、卵白蛋白+地塞米松组和卵白蛋白+普仑司特组，每组10只，分别给予卵白蛋白鼻内激发1、8、12周，观察地塞米松和普仑司特的作用。在12周的鼻内暴露于卵清蛋白，后两组每天分别接受地塞米松和普仑司特腹腔注射。卵清蛋白持续刺激可引起鼻黏膜和外耳道组织发生明显的病理改变，包括嗜酸性粒细胞浸润、杯状细胞增生、上皮细胞损伤和细胞外基质沉积。与阴性对照组相比，卵白蛋白致敏组表现出明显的杯状细胞增生、上皮损伤和细胞外基质沉积。地塞米松和普仑司特钠分别显著抑制这些变化。我们建立了豚鼠上气道重塑模型。组织重建被抑制的早期干预与过敏性炎症剂地塞米松和普仑司特