Elucidation and control of mechanisms of mucus hypersecretion in the intractable upper airway diseases

顽固性上呼吸道疾病粘液分泌过多的机制的阐明和控制

• 批准号: 22591899
• 负责人: TAKEUCHI Kazuhiko
• 金额: $ 2.83万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591899/
• 关键词: 鼻科学; ムチン遺伝子; アレルギー性炎症; 好酸球性副鼻腔炎; TGF-α; TNF-α; MUC5AC; マクロライド; デキサメサゾン; 好酸球; 副鼻腔炎; ムチン; 粘液; エンテロトキシン; NF-kB

TGF-α immunoreactivity was found markedly increased in the submucosal tissue in the eosinophilic chronic rhinosinusitis patient compared with that of a normal patient and with noneosinophilic chronic rhinosinusitis. TGF-α synergized with TNF-α to upregulate MUC5AC expression in human epithelial cells through the ERK signaling pathway. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. These findings suggest that IL-31 plays an important role in mucus overproduction in nasal allergic inflammation. A new erythromycin derivative, EM900, does not have antibacterial action.EM900 suppressed induction of inflammatory cytokines and MUC5AC gene expression in cells derived from human airway epithelia, and our findings indicated that these effects may be mediated by the suppression of NF-κB activation.

嗜酸性慢性鼻窦炎患者粘膜下组织TGF-α免疫反应性明显高于正常人和非嗜酸性慢性鼻窦炎患者。TGF-α与TNF-α通过ERK信号通路协同上调人上皮细胞MUC 5AC表达。IL-31和IL-31 RA在变应性鼻炎患者中上调，并诱导人气道上皮细胞中MUC 5AC基因表达。这些发现表明IL-31在鼻过敏性炎症中的粘液过度产生中起重要作用。新的红霉素衍生物EM 900不具有抗菌作用，EM 900可抑制人气道上皮细胞中炎症因子的诱导和MUC 5AC基因的表达，我们的研究结果表明，这种作用可能是通过抑制NF-κB的激活来介导的。

项目成果

Effects of Interleukin-31 onMUC5AC Gene Expression in Nasal

IL-31对鼻腔MUC5AC基因表达的影响

• 发表时间: 2013
• 期刊: Allergic Inflammation. Pharmacology
• 作者: Shah SA;Ishinaga H;Hou B;Okano M;Takeuchi K.
• 通讯作者: Takeuchi K.

ヒト気道上皮でのムチン遺伝子発現に対するIL-31の影響

IL-31对人气道上皮粘蛋白基因表达的影响

• 发表时间: 2012
• 作者: 石永一;竹内万彦
• 通讯作者: 竹内万彦

Effect of clarithromycin and dexamethasone on mucus production in isografted rat trachea

克拉霉素和地塞米松对同种移植大鼠气管粘液产生的影响

• 发表时间: 2011
• 期刊: Pharmacology
• 影响因子: 3.1
• 作者: Kitano M;Ishinaga H;et al.
• 通讯作者: et al.

Two cases of Kartagener's syndrome

卡塔格纳综合征两例

• 发表时间: 2011
• 作者: Sakaida H;Sakaida M;Shibata T;Ogawa S;Nakatani K;Takeuchi K
• 通讯作者: Takeuchi K

The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis

转化生长因子-α 对嗜酸性慢性鼻-鼻窦炎粘蛋白过量产生的作用

• DOI: 10.1159/000333794
• 发表时间: 2011
• 期刊: Pharmacology
• 影响因子: 3.1
• 作者: Ishinaga H;Shah SA;Sakaida H,Takeuchi K
• 通讯作者: Sakaida H,Takeuchi K