Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological tool

点击翻译按钮获取中文摘要

The evaluation method using reactive hyperemia (RHE) to measure endothelial function is useful for detecting the early phase of atherosclerotic changes. Atherosclerotic changes like peripheral arterial disease are found much more in legs than in arms, however, the current methods for evaluating endothelial function with ultrasound graph (FMD) or peripheral tonometry (EndoPAT) are limited to ‘arm’ RHE due to technical difficulties in measuring ‘leg’ RHE. The present study established a novel method to measure ‘leg’ RHE by using a near-infrared time-resolved spectroscopy (NIRTRS). In arm RHE measured by NIRTRS, there was no difference of RHE patterns among 20s, 50s and 70s men groups, however the leg RHE patterns of 50s and 70s men groups were lower than that of 20s men group. Thus, the leg RHE measured by NIRTRS could be a biomarker for detecting the early phase of aging changes in vascular function and evaluating drug effectson the vascular functional changes.