Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic stroke
Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic stroke
批准号:
19590244
负责人:
TAKEUCHI Kazuhiko
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
主なヒト血中遊離脂肪酸中、ω6多価不飽和脂肪酸であるアラキドン酸とリノール酸は、血管内皮細胞内カルシウム応答の抑制を介して内皮依存性血管拡張因子(プロスタグランジンI_2及びNO)の産生を低下させた。しかし、他の遊離脂肪酸には、このような抑制効果はみられなかった。アラキドン酸による血管内皮機能抑制作用がアラキドン酸-20-HETE(脳血管攣縮への関与が報告されている)経路を介したものであるかを検討したが、有意な結果は得られなかった。これらの結果は、脳心血管イベントをはじめとする血管機能障害と遊離脂肪酸との関連を考える際に、遊離脂肪酸のプロファイルが重要であることが明らかとなった。
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Free fatty acids(FFAs), arachidonic and linoleic acids but not other FFAs, suppress endothelial function by inhibiting endothelial Ca^<2+> responses
游离脂肪酸 (FFA)、花生四烯酸和亚油酸(而非其他 FFA)通过抑制内皮 Ca^2 反应来抑制内皮功能
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takeuchi K, Watanabe H.]
通讯作者:
Watanabe H.
DOI:
10.1007/s00210-007-0243-x
发表时间:
2008-06-01
期刊:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
影响因子:
3.6
作者:
[Asai, Masayoshi, Takeuchi, Kazuhiko, Watanabe, Hiroshi]
通讯作者:
Watanabe, Hiroshi
Omega-6 polyunsaturated fatty acids, arachidonic and linoleic acids, but not other free fatty acids, suppress endothelial Ca^<2+> signaling and functions
Omega-6 多不饱和脂肪酸、花生四烯酸和亚油酸,但不包括其他游离脂肪酸,可抑制内皮 Ca^2 信号传导和功能
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takeuchi K, Watanabe H.]
通讯作者:
Watanabe H.
DOI:
10.1093/cvr/cvp105
发表时间:
2009-07-01
期刊:
CARDIOVASCULAR RESEARCH
影响因子:
10.8
作者:
[Asai, Masayoshi, Takeuchi, Kazuhiko, Watanabe, Hiroshi]
通讯作者:
Watanabe, Hiroshi
酸性環境下における血管内皮機能
酸性环境下血管内皮功能
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[竹内和彦, 浅井正嘉, 渡邉裕司]
通讯作者:
渡邉裕司
共 7 条
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Studies on the influences of large-scale landform transformation on remained forest community and planted tree population in residential development
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