Verification of the relationship between fat cells and lymphangiogenesis by using a benign lymphangioma model

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In an adjuvant-induced lymphangioma model, we found that abdominal mesothelial cells and bone marrow-derived cells proliferated and transformed into fat storing cells in response to extrinsic mineral oil, and then, by fusing with each other, formed tubular structures which appeared to be morphologically and functionally immature lymphatic vessels. This suggests that mesothelium, fat cell and lymphatic endothelium may be interchangeable to each other depending on their local microenvironment.