New approach for detoxication of toxic substances in foods and the evaluation

食品中有毒物质解毒新方法及评价

• 批准号: 19500675
• 负责人: KONISHI Yoshiko
• 金额: $ 2.91万
• 依托单位: National Institute of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500675/
• 关键词: デトックス; 調理・加工; 安全性; カビ毒; デオキシニバレノール; マウス; 吸収率; ペクチンゲル; ペクチン; 減衰; エッグボックス; ハーブ; ニバレノール

Mycotoxin is natural contaminant and cause adverse effects on human and animal health. Since it is too hard for mycotoxin to reach zero tolerance, many approachs to reduce intake mycotoxin from final food products have been tried. However the developed tools until now has advantages and disadvantages. Therefore the development of new method for reduction of exposure to mycotoxins is needed on food processing.In this study, we developed pectin gelation containing mycotoxin (DON) and examined suppressive effect on absorption of deoxynivalenol (DON). As pectin, low methoxy non-amidate (LMNA) pectin and amidate (LMA) pectin were used. The gelation using LMA pectin was effective for sealing DON into gel at 4℃ and 37℃. In vivo experiment revealed that the gelation suppressed the absorption of DON in gastro-intestine.The LMA pectin would be valuable processing tool to reduce the exposure to mycotoxin.

霉菌毒素是天然污染物的，对人类和动物健康造成不利影响。由于霉菌毒素太难达到零耐受性，因此已经尝试了许多减少最终食品摄入霉菌毒素的方法。但是，到目前为止，开发的工具具有优势和缺点。因此，在食品加工中需要开发减少霉菌毒素暴露的新方法。在这项研究中，我们开发了含有霉菌毒素（DON）的果胶凝胶化，并检查了对脱氧基因烯醇（DON）丧失的抑制作用。作为果胶，使用了低方法溶解非耐药（LMNA）果胶和阿米丁（LMA）果胶。使用LMA果胶的凝胶化可有效地将DON密封在4℃和37℃的凝胶中。体内实验表明，凝胶化抑制了胃肠道中DON的损失。LMA果胶将是减少霉菌毒素暴露的有价值的加工工具。

项目成果

A Survey of the Occurrence of Fusarium Mycotoxins in Biscuits in Japan by Using LC/MS

• DOI: 10.1248/jhs.56.188
• 发表时间: 2010-04
• 期刊: Journal of Health Science
• 作者: Hiroki Tanaka;Y. Sugita‐Konishi;M. Takino;Toshitsugu Tanaka;A. Toriba;K. Hayakawa

Detection of deoxynivalenol contamination in wheat products in Thailand

• DOI: 10.4315/0362-028x-71.9.1931
• 发表时间: 2008-09-01
• 期刊: JOURNAL OF FOOD PROTECTION
• 影响因子: 2
• 作者: Poapolathep, Amnart;Poapolathep, Saranya;Kumagai, Susumu
• 通讯作者: Kumagai, Susumu

Suppressive Effect of Pectin Gelation on Absorption of Deoxynivalenol in Mice.

果胶凝胶化对小鼠脱氧雪腐镰刀菌烯醇吸收的抑制作用。

• 发表时间: 2010
• 作者: Sugita-Konishi;Y.;Koyama;D.;Kadota;T.;Itoh;S.;Sugiyama;K.;Tamura;C.;Nishijima;M. Kamata;Y.
• 通讯作者: Y.

Effect of deoxynivalenol on LPS signaling in macrophage

脱氧雪腐镰刀菌烯醇对巨噬细胞 LPS 信号传导的影响

• 发表时间: 2007
• 作者: Sugiyama;K.;Muroi;M.;Tanamoto';K.;Nishijima;M.;Sugita-Konishi'Y.
• 通讯作者: Sugita-Konishi'Y.