Development of early-diagnosis and made-to-order immunotherapy fororal cancers by using cancer-specific peptides

充分了解肿瘤的免疫监视和调节机制，是利用肿瘤特异性肽进行肿瘤早期诊断和定制免疫治疗的基础。在本研究中，SART-1被鉴定为在口腔癌上表达的多种癌症特异性肽中具有最强的抗原性，并且在针对口腔癌的免疫监视中起核心作用，这表明SART-1最有希望应用于口腔癌的治疗和诊断。相反，揭示了肿瘤相关抗原RCAS 1在口腔癌上表达并分泌，诱导活化的T细胞凋亡，从而抑制对口腔癌的免疫监视。为了增强对口腔癌的免疫监视，强烈建议应实现RCAS1的功能调节以及SART-1的接种。

Fully understanding of immune surveillance and regulation against cancers is needed to develop early-diagnosis and made-to-order immunotherapy for cancers by using cancer-specific peptides. In this study, SART-1 was identified to have strongest antigenicity among various cancer-specific peptides expressed on oral cancersand to play a central part in immune surveillance against oral cancers, indicating that SART-1 is most promisingly applicable to the treatment and diagnosis of oral cancers.In contrast, it was revealed that a tumor-associated antigen, RCAS1, was expressed on and secreted from oral cancers, induced apoptosis of activated T cells, and thussuppressed immune surveillance against oral cancers. To augment immune surveillance against oral cancers, it was strongly suggested that functional regulation of RCAS1, as well as inoculation of SART-1, should be achieved.