'The lung- gut network'contributes to development of chronic obstructive pulmonary disease (COPD).

“肺-肠网络”导致慢性阻塞性肺病（COPD）的发展。

• 批准号: 20590903
• 负责人: YOSHIKAWA Masanori
• 金额: $ 2.33万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590903/
• 关键词: 慢性閉塞性肺疾患; 全身性炎症; 肺-消化管ネットワーク; 喫煙; 腸内環境; 全身炎症

In smoke exposed animals, food intake and body weight gain were less than those in non-smoking controls while plasma acyl-ghrelin levels were elevated. In addition, the change in bacterial flora and decrease in short chain fatty acids in cecum were found. Supplementation of fiber-free diet resulted in remarkable suppression of body weight gain, deterioration of gut environment and the reduction of serum antioxidant activity. It was shown that discontinuous feeding with fiber-free diet accelerated elastase- induced emphysema in smoke exposed rats, while amount of food intake did not decreased.These data suggest that deterioration of gut environment by cigarette smoke may contribute to nutritional depletion and systemic inflammation, which in turn may develop the pulmonary emphysema. In conclusion, we have demonstrated an existence of lung-gut network which may be associated with the development of chronic obstructive lung disease.

在暴露于烟雾的动物中，食物摄入量和体重增加少于不吸烟的对照组，而血浆酰基生长素释放肽水平升高。此外，还发现盲肠细菌菌群的变化和短链脂肪酸的减少。补充无纤维饮食会显着抑制体重增加、肠道环境恶化和血清抗氧化活性降低。结果表明，间断喂养无纤维饮食会加速暴露于烟雾的大鼠中弹性蛋白酶诱发的肺气肿，而食物摄入量并未减少。这些数据表明，香烟烟雾导致的肠道环境恶化可能导致营养耗竭和全身炎症，进而可能发展为肺气肿。总之，我们证明了肺肠网络的存在，可能与慢性阻塞性肺病的发展有关。

项目成果

エラスターゼ誘導肺気腫は繊維除去食および欠食で促進する

无纤维饮食和不进餐会促进弹性蛋白酶诱发的肺气肿

• 发表时间: 2011
• 作者: 友田恒一;吉川雅則
• 通讯作者: 吉川雅則

喫煙暴露により腸内環境は変化する

吸烟改变肠道环境

• 发表时间: 2008
• 作者: 小林信也;友田恒一;山本佳史;吉川雅則;木村弘
• 通讯作者: 木村弘

Discontinuous feeding with fiber-free diet accelerates elastase-induced emphysema in rats

间断喂养无纤维饮食会加速大鼠弹性蛋白酶诱导的肺气肿

• 发表时间: 2011
• 作者: Tomoda K.;Yoshikawa M.;et al
• 通讯作者: et al

Impact of cigarette smoke on plasma levels of adipocytokines

香烟烟雾对血浆脂肪细胞因子水平的影响

• 发表时间: 2009
• 作者: 友田恒一;吉川雅則;et al.
• 通讯作者: et al.

Cellulose free diet suppresses antioxidant activity and accelerates adecrease in body weight gain during exposure to cigarette smoking in mice

无纤维素饮食抑制小鼠吸烟期间的抗氧化活性并加速体重增加

• 发表时间: 2009
• 作者: 友田恒一;吉川雅則;et al.
• 通讯作者: et al.