An Efficient Access to Chiral Compounds via Asymmetric Hydrogenation of Polar Functional Groups

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Novel molecular catalysts have been developed for the straightforward hydrogenation of a range of carboxylic acid derivatives under mild conditions. Modular design of chiral molecular catalysts could provide direct access to stereochemically well-defined moleculres, which might otherwise have required a detour to reach. Another important finding in this study is that the coexistence of inorganic base has led to dramatic improvement in their catalytic activity.