The roles for chemokines in induction and maintenance of humoral immunity or cell-mediated immunity

点击翻译按钮获取中文摘要

The roles for chemokines CCL19 and CCL21 in induction of humoral immunity or cell-mediated immunity were investigated using plt mutant mice, which lack expression of CCL19 and CCL21-ser in their lymphoid organs. When the mice were immunized with ovalbumin(OVA) in adjuvant, the amount of anti-OVA IgG in serum was higher in plt mice as compared to BALB/c WT mice. However, the antigen specific CTL induction inhibited in plt mice. These findings indicate that CCL19 and CCL21 induce prompt antibody responses to antigen, and regulate T cell responses in vivo.