The roles for chemokines in induction and maintenance of humoral immunity or cell-mediated immunity

趋化因子在诱导和维持体液免疫或细胞介导的免疫中的作用

• 批准号: 21790963
• 负责人: TANAKA Yuriko
• 金额: $ 2.83万
• 依托单位: Toho University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790963/
• 关键词: ケモカイン; 細胞性免疫; 体液性免疫; 免疫学; アジュバント; T細胞プライミング; pltマウス

The roles for chemokines CCL19 and CCL21 in induction of humoral immunity or cell-mediated immunity were investigated using plt mutant mice, which lack expression of CCL19 and CCL21-ser in their lymphoid organs. When the mice were immunized with ovalbumin(OVA) in adjuvant, the amount of anti-OVA IgG in serum was higher in plt mice as compared to BALB/c WT mice. However, the antigen specific CTL induction inhibited in plt mice. These findings indicate that CCL19 and CCL21 induce prompt antibody responses to antigen, and regulate T cell responses in vivo.

使用 plt 突变小鼠研究了趋化因子 CCL19 和 CCL21 在诱导体液免疫或细胞介导的免疫中的作用，这些小鼠的淋巴器官中缺乏 CCL19 和 CCL21-ser 的表达。当用佐剂中的卵清蛋白(OVA)免疫小鼠时，与BALB/c WT小鼠相比，plt小鼠血清中抗OVA IgG的量较高。然而，抗原特异性CTL诱导在plt小鼠中受到抑制。这些发现表明 CCL19 和 CCL21 诱导针对抗原的快速抗体反应，并调节体内 T 细胞反应。

项目成果

Liposome-Coupled Antigens Are Internalized by Antigen-Presenting Cells via Pinocytosis and Cross-Presented to CD8+ T Cells

• DOI: 10.1371/journal.pone.0015225
• 发表时间: 2010-12-17
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Tanaka, Yuriko;Taneichi, Maiko;Uchida, Tetsuya
• 通讯作者: Uchida, Tetsuya

The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer

• DOI: 10.1007/s00262-010-0877-2
• 发表时间: 2010-10-01
• 期刊: CANCER IMMUNOLOGY IMMUNOTHERAPY
• 影响因子: 5.8
• 作者: Kobayashi, Kouichi;Tanaka, Yuriko;Okamoto, Yoshitaka
• 通讯作者: Okamoto, Yoshitaka

Soluble protein antigen efficiently elicits T cell response without any adjuvant in mutant mice lacking expression of CCL19 and CCL21 (plt mice)

可溶性蛋白抗原在缺乏 CCL19 和 CCL21 表达的突变小鼠（plt 小鼠）中有效引发 T 细胞反应，无需任何佐剂

• 发表时间: 2010
• 作者: 田中ゆり子;桑原卓;石川文雄;垣内史堂
• 通讯作者: 垣内史堂

Acute ethanol inhalation down-regulates IL12 production by dendritic cells and enhances Th2 polarization

急性乙醇吸入下调树突状细胞 IL12 的产生并增强 Th2 极化

• 发表时间: 2009
• 作者: Fumio Ishikawa;Taku Kuwabara;Yuriko Tanaka;Naomi Yamashita;Terutaka Kakiuch
• 通讯作者: Terutaka Kakiuch

Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells.

脂质体偶联肽无需 CD4 T 细胞即可诱导长寿命记忆 CD8 T 细胞。

• 发表时间: 2010
• 期刊: PLos One. Vol.5, issue 11
• 作者: Taneichi M.;Tanaka Y.;Kakiuchi T.;Uchida T.
• 通讯作者: Uchida T.