To determine the intracellular signaling of keloid fibroblasts; especially the responses of purinoceptors

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The purpose of the research is to determine the difference between intracellular signaling of normal fibroblasts and keloid fibroblasts, with emphasis on the responses of adenosine triphosphate (ATP) and purinoceptors. Fibroblasts were isolated from keloid and normal skin tissue that were obtained from human skin. Each cell has the specific responses of extracellular ATP. Fluorescent staining showed that each cell has the specific arrangement of cytoskeleton (F-actin) and endoplasmic reticulum density.