Investigation of TBK1 activation mechanism

TBK1 （TANK Binding Kinase 1）是宿主防御病毒或微生物感染的重要基因。TBK1的激活机制尚不清楚。本研究通过筛选细胞成分研究了Ptdins5P的激活机制，发现Ptdins5P在病毒感染过程中作为先天免疫反应的信号介质。此外，通过TBK1信号激活，合成Ptdins5P免疫抗原诱导抗原特异性抗体。

TBK1 (TANK Binding Kinase 1) is important gene for host defence against virus or microbes infection. Activation mechanism for TBK1 is still unclear. Here we investigated activation mechanism by screening cellular component, and found that Ptdins5P works as signaling mediator for innate immune response during virus infection. Furthermore, synthetic Ptdins5P immunization with antigen induced antigen specific antibody production by TBK1 signaling activation.