Analysis of autoantibodies for targeting pathogenesis and therapyof misfolding diseases

我们检测了转基因大鼠和家族性淀粉样变性多发性神经病(FAP ATTRV30M)中是否存在抗变异型反式甲状腺激素(TTR)抗体。在相当数量的日本和瑞典FAP患者中，存在这种抗体。所有患者均为晚发病例。列出了ATTR24-35和105-115作为TTR变异体的表位。当我们考虑FAP的新疗法时，这一发现是非常重要的，并为基础治疗提供了一些提示。

We examined presence or absence of anti-variant transthyretin (TTR) antibody in both transgenic rats and familial amyloidotic polyneuropathy (FAP ATTR V30M). In significant numbers of Japanese and Swedish FAP patients, the antibody was present. All patients were late onset cases. As epitopes of TTR variant, ATTR24-35, and 105-115 were listed. When we consider the novel therapy for FAP, this findings are very important and give some hint for the essential therapy.