Bioinformatics and Genomics Core

生物信息学和基因组学核心摘要 NH-INBRE生物信息学和基因组学核心(BGC)的总体目标是克服 通过直接支持正在进行的研究项目和新的研究项目以及促进 将生物信息学纳入本科课程。合作伙伴和研究项目的支持需求 牵头机构贯穿从实验设计到出版的所有阶段。这包括访问 由NH-INBRE支持的最先进的计算基础设施。解决以下问题的长期目标 在生物信息学的广泛劳动力培训方面，我们开发了一套资源来支持核心生物信息学 在生物课程的背景下进行培训。在NH-INBRE BGC的下一阶段，我们建议扩展 生物信息学研究的支持范围和这些课程模块的实施 通过利用全国IDEA网络的参与，在新罕布夏州和全国范围内开展了这一活动。最后，我们 打算进一步扩展这一课程支持，并将重点放在严谨和透明上 生物信息学。为了实现这些目标，我们有三个具体目标： 目标1：提高新罕布夏州的生物医学研究能力 本科院校和NH-INBRE的两所主要大学：a)支持NH-INBRE 研究项目并通过在不同领域的培训增强整个网络的生物信息学专业知识 生物信息学应用；b)提供可持续、可获得、成本效益高和管理良好的 用于数据分析、存储和传播的计算基础设施。 目标2：通过继续为生物信息学培训创建可持续、可扩展和有影响力的机制 支持生物信息学融入本科理科课程。。在这一资助期， 我们建议将这一课程支持计划扩展到至少四个额外的INBRE生物信息学核心 四个IDEA地理区域中的每一个，长期目标是扩展到INBRE的所有24个项目。 目标3：建立劳动力发展培训和基础设施，以促进严谨和 生物信息学的重现性：a)促进生物信息学分析的透明度；b)建立 为INBRE资助的研究提供准确数据和方法的最佳实践。 实现这些目标将支持关键技能和严格实践的发展，符合 NIH数据科学战略计划中定义的总体目标。特别是，我们的培训和支持 执行公平原则，其中数据和分析应是可查找、可访问、可互操作和 可重复使用。

III. Bioinformatics and Genomics Core Abstract The overall goal of the NH-INBRE Bioinformatics and Genomics Core (BGC) is to overcome the gap in bioinformatics expertise by direct support of ongoing and new research projects and fostering integration of bioinformatics into the undergraduate curriculum. The need for support for research projects at Partner and Lead institutions extends through all phases from experimental design to publication. This includes access to state-of-the-art computational infrastructure supported by the NH-INBRE. To address the long-term goals for broad workforce training in bioinformatics, we have developed a set of resources to support core bioinformatics training in the context of a biology curriculum. In the next phase of our NH-INBRE BGC, we propose to expand both the scope of bioinformatics research support and implementation of these curriculum modules both within New Hampshire and nationally by leveraging the participation of the nationwide IDeA network. Finally, we intend to further extend this curriculum support and integrate an important focus on rigor and transparency in bioinformatics. To accomplish these goals, we have three specific aims: Aim 1: Improve the biomedical research capacity of the State of New Hampshire at the eight primarily undergraduate institutions and the two Lead universities of the NH-INBRE by: a) Supporting NH-INBRE research projects and enhancing bioinformatics expertise across the network through training in diverse bioinformatics applications; b) Providing sustainable, accessible, cost-effective, and well-managed computational infrastructure for data analysis, storage, and dissemination. Aim 2: Create a sustainable, scalable, and impactful mechanism for bioinformatics training by continuing to support the integration of bioinformatics into the undergraduate science curriculum. . For this funding period, we propose to extend this curricular support program to at least four additional INBRE Bioinformatics Cores in each of the four IDeA geographical regions, with the long-term goal to extend across all 24 INBRE programs. Aim 3: Establish workforce development training and infrastructure for advancement of Rigor and Reproducibility in bioinformatics by a) Promoting transparency of bioinformatics analysis and b) Establishing best practices for accurately presenting data and methods for INBRE-funded research. Achieving these goals will support the development of key skills and rigorous practices in line with the overarching goals as defined in the NIH strategic plan for data science. In particular, our training and support enforces the FAIR principles where data and analysis should be Findable, Accessible, Interoperable and Reusable.