Bioinformatics and Genomics Core

生物信息学和基因组学核心

• 批准号: 10436191
• 负责人: WILLIAM R GREEN
• 金额: $ 25.18万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436191
• 关键词: Address; Bioinformatics; Biology; Biomedical Research; Cancer Education Grant Program; Collaborations; Data; Data Analyses; Data Science; Development; Education; Educational Curriculum; Ensure; Evaluation; Evolution; Experimental Designs; FAIR principles; Faculty; Fostering; Funding; Future; Generations; Genomics; Geographic Locations; Goals; Grant; Institution; Kansas; Lead; Measures; Methods; New Hampshire; Phase; Publications; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Strategic Planning; Teacher Professional Development; Trainers Training; Training; Training Activity; Training Programs; Training Support; Training and Infrastructure; United States National Institutes of Health; Universities; Workforce Development; computer infrastructure; cost effective; experience; improved; informatics training; innovation; programs; skills; student training; success; undergraduate student

III. Bioinformatics and Genomics Core Abstract The overall goal of the NH-INBRE Bioinformatics and Genomics Core (BGC) is to overcome the gap in bioinformatics expertise by direct support of ongoing and new research projects and fostering integration of bioinformatics into the undergraduate curriculum. The need for support for research projects at Partner and Lead institutions extends through all phases from experimental design to publication. This includes access to state-of-the-art computational infrastructure supported by the NH-INBRE. To address the long-term goals for broad workforce training in bioinformatics, we have developed a set of resources to support core bioinformatics training in the context of a biology curriculum. In the next phase of our NH-INBRE BGC, we propose to expand both the scope of bioinformatics research support and implementation of these curriculum modules both within New Hampshire and nationally by leveraging the participation of the nationwide IDeA network. Finally, we intend to further extend this curriculum support and integrate an important focus on rigor and transparency in bioinformatics. To accomplish these goals, we have three specific aims: Aim 1: Improve the biomedical research capacity of the State of New Hampshire at the eight primarily undergraduate institutions and the two Lead universities of the NH-INBRE by: a) Supporting NH-INBRE research projects and enhancing bioinformatics expertise across the network through training in diverse bioinformatics applications; b) Providing sustainable, accessible, cost-effective, and well-managed computational infrastructure for data analysis, storage, and dissemination. Aim 2: Create a sustainable, scalable, and impactful mechanism for bioinformatics training by continuing to support the integration of bioinformatics into the undergraduate science curriculum. . For this funding period, we propose to extend this curricular support program to at least four additional INBRE Bioinformatics Cores in each of the four IDeA geographical regions, with the long-term goal to extend across all 24 INBRE programs. Aim 3: Establish workforce development training and infrastructure for advancement of Rigor and Reproducibility in bioinformatics by a) Promoting transparency of bioinformatics analysis and b) Establishing best practices for accurately presenting data and methods for INBRE-funded research. Achieving these goals will support the development of key skills and rigorous practices in line with the overarching goals as defined in the NIH strategic plan for data science. In particular, our training and support enforces the FAIR principles where data and analysis should be Findable, Accessible, Interoperable and Reusable.

三.生物信息学和基因组学核心摘要 NH-INBRE生物信息学和基因组学核心（BGC）的总体目标是克服以下方面的差距： 生物信息学专业知识，直接支持正在进行的和新的研究项目，并促进整合 生物信息学纳入本科课程。需要支持合作伙伴的研究项目， 牵头机构贯穿从实验设计到出版的所有阶段。这包括获得 由NH-INBRE支持的最先进的计算基础设施。为了实现长期目标， 在生物信息学的广泛劳动力培训，我们已经开发了一套资源，以支持核心生物信息学 在生物学课程的背景下进行培训。在我们的NH-INBRE BGC的下一阶段，我们建议扩大 生物信息学研究支持的范围和这些课程模块的实施， 新罕布什尔州和全国范围内利用全国性的IDEA网络的参与。最后我们 打算进一步扩大这一课程支持，并将严格性和透明度作为一个重要重点， 生物信息学为了实现这些目标，我们有三个具体目标： 目标1：提高新罕布什尔州的生物医学研究能力， 本科院校和NH-INBRE的两所牵头大学，方法是： 研究项目，并通过各种培训提高整个网络的生物信息学专业知识 生物信息学应用; B）提供可持续的，可获得的，具有成本效益的，管理良好的 用于数据分析、存储和传播的计算基础设施。 目标2：为生物信息学培训创建一个可持续、可扩展和有效的机制， 支持将生物信息学纳入本科科学课程。.在这段供资期间， 我们建议将这一课程支持计划扩展到至少四个额外的INBRE生物信息学核心， 四个IDEA地理区域中的每一个，长期目标是扩展到所有24个INBRE项目。 目标3：建立劳动力发展培训和基础设施，以促进严谨性， 生物信息学中的复制：a）提高生物信息学分析的透明度; B）建立 为国家生物多样性研究所资助的研究准确提供数据和方法的最佳做法。 实现这些目标将有助于发展关键技能和严格的做法， NIH数据科学战略计划中定义的总体目标。特别是我们的培训和支持 实施公平原则，即数据和分析应该是可查找的、可解释的、可互操作的， 可重复使用。