Center for Molecular, Cellular, and Translational Immunology

分子、细胞和转化免疫学中心

• 批准号: 8116197
• 负责人: WILLIAM R GREEN
• 金额: $ 118.5万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116197
• 关键词: Center; Molecular; Cellular; Translational; Immunology

DESCRIPTION (provided by applicant): Based on the success of the initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunological faculty, especially those investigators previously supported by COBRE; expansion of the COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the University of Vermont; and an enhanced Pilot Project Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

描述（由申请人提供）：基于最初的10年奖励的成功，这个COBRE更新申请的最终目标是在达特茅斯完成一个国家认可的分子、细胞和转化免疫学研究中心的建立，并在五年内将这个COBRE免疫学研究中心（COBRE- cir）转变为一个基于基础设施的、独立的（由COBRE资助）、可持续的中心。在长期免疫学项目的基础上，该项目现已得到COBRE的大力支持，该提案充分利用了达特茅斯医学院（DMS）和达特茅斯希区柯克医疗中心（DHMC）高度互动的核心合作教师。随着研究人员基数的扩大，第三期COBRE奖将为建立所需的基础设施提供资源，以维持COBRE- cir，进一步发展该项目，并促进跨学科基础科学转化免疫学研究。该基础设施将包括我们的免疫学教师的持续指导发展，特别是那些以前由COBRE支持的研究人员；扩展COBRE核心，并充分整合DMS/DHMC现有的互补核心和共享服务，特别是Norris Cotton癌症中心和达特茅斯大学和佛蒙特大学的其他免疫学和“肺生物学”COBRE；以及针对指导、协作和/或转化/人类系统研究的强化试点项目计划。加上DMS/DHMC的实质性机构承诺，我们有信心，COBRE机制已经扩大和成熟了强大的现有研究人员队伍，可以进一步发展，以完成形成一个可持续的免疫研究中心，该中心以优秀的基础科学研究为基础，采用转化方法促进假设驱动研究的双向从实验室到床边应用，并具有区域，如果不是全国性的，影响也是巨大的。