Center for Molecular, Cellular, and Translational Immunology

分子、细胞和转化免疫学中心

• 批准号: 8116197
• 负责人: WILLIAM R GREEN
• 金额: $ 118.5万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116197
• 关键词: Center; Molecular; Cellular; Translational; Immunology

DESCRIPTION (provided by applicant): Based on the success of the initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunological faculty, especially those investigators previously supported by COBRE; expansion of the COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the University of Vermont; and an enhanced Pilot Project Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

描述（由申请人提供）：基于最初 10 年奖的成功，本次 COBRE 续签申请的最终目标是在达特茅斯完成国家认可的分子、细胞和转化免疫学研究中心的建立，并在五年内将这个 COBRE 免疫学研究中心 (COBRE-CIR) 转变为一个基于基础设施的、独立的（由 COBRE 资助）、可持续的中心。该提案以长期免疫学项目为基础，现已在 COBRE 的支持下得到大幅加强，利用了达特茅斯医学院 (DMS) 和达特茅斯希区柯克医疗中心 (DHMC) 高度互动的合作教师核心。随着研究人员基础的扩大，第三阶段 COBRE 奖项将提供资源来建设所需的基础设施，以维持 COBRE-CIR，进一步发展该计划，并促进跨学科基础科学到转化免疫学研究。该基础设施将包括我们免疫学教师的持续指导发展，特别是那些以前由 COBRE 支持的研究人员；扩展 COBRE 核心，并将其与 DMS/DHMC 现有的补充核心和共享服务完全整合，特别是诺里斯·科顿癌症中心以及达特茅斯和佛蒙特大学的其他免疫学和“肺生物学”COBRE；以及一个增强的试点项目计划，旨在指导、协作和/或转化/人类系统研究。加上 DMS/DHMC 的实质性机构承诺，我们相信，COBRE 机制已经扩大和成熟的强大的现有研究人员队伍可以得到进一步发展，以完成可持续的免疫学研究中心的形成，该中心以优秀的基础科学研究为基础，采用转化方法来促进假设驱动研究的双向实验室到临床应用，并拥有区域性（如果不是全国性的）、 影响。