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Center for Molecular, Cellular, and Translational Immunology

分子、细胞和转化免疫学中心

基本信息

批准号：
8847733
负责人：
WILLIAM R GREEN
金额：
$ 117.42万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8847733
关键词：
Antigens Autoimmunity Award Basic Science Biology Biomedical Research Centers of Research Excellence Characteristics Communicable Diseases Consultations Core Facility Development Disease Doctor of Medicine Doctor of Philosophy Education Ensure Faculty Flow Cytometry Shared Resource Foundations Funding Goals Human Hypersensitivity Immune response Immune system Immunologic Monitoring Immunology Infection Inflammation Institutes Instruction Investigation Laboratories Lung Malignant Neoplasms Medical center Mentors Mission Molecular Mus National Center for Research Resources National Institute of Allergy and Infectious Disease Natural Immunity Norris Cotton Cancer Center Patient Care Phase Pilot Projects Qualifying Research Research Infrastructure Research Personnel Research Support Resources Services Speed Syndrome Technology Transgenic Organisms United States National Institutes of Health Universities Vaccines Vermont base bench to bedside career catalyst congenic immunopathology medical schools microbial operation programs response success systems research translational approach tumor

项目摘要

Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

基于最初10年奖励的成功，此次COBRE更新申请的最终目标是完成在达特茅斯建立一个国家认可的分子，细胞，转化免疫学研究，并将这个COBRE免疫学研究中心（COBRE-CIR）到一个基于基础设施的，独立的（来自COBRE资金），可持续发展的中心，年随着一个长期的免疫学计划的基础，现在已经大大在COBRE的支持下，该提案利用了高度互动的协作核心，达特茅斯医学院（DMS）和达特茅斯希区柯克医疗中心（DHMC）的教师。与此为了扩大研究人员的基础，第三阶段COBRE奖将提供资源，以建立所需的基础设施，以维持COBRE-CIR，进一步发展该计划，并促进跨学科的基本转化免疫学研究。这一基础设施将包括继续指导发展我们的免疫学能力，特别是那些以前由COBRE支持的研究人员; COBRE核心的扩展及其与现有互补核心的完全集成， DMS/DHMC的服务，特别是诺里斯棉花癌症中心和其他免疫学和“肺” 达特茅斯和佛蒙特大学的生物学”COBREs;以及增强的试点项目计划以指导、协作和/或翻译/人类系统研究为目标。连同移民管理局/人权监察委员会的实质性机构承诺，有信心，调查人员已经通过COBRE机制得到了扩展和成熟，可以进一步发展，完成一个可持续的免疫学研究中心的形成，该中心以优秀的基础科学研究，包括一个转化的方法，以促进双向的板凳到床边这是一个假设驱动的研究的应用，并具有区域性，如果不是也是国家性的影响。