Center for Molecular, Cellular, and Translational Immunology
分子、细胞和转化免疫学中心
基本信息
- 批准号:8847733
- 负责人:
- 金额:$ 117.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:AntigensAutoimmunityAwardBasic ScienceBiologyBiomedical ResearchCenters of Research ExcellenceCharacteristicsCommunicable DiseasesConsultationsCore FacilityDevelopmentDiseaseDoctor of MedicineDoctor of PhilosophyEducationEnsureFacultyFlow Cytometry Shared ResourceFoundationsFundingGoalsHumanHypersensitivityImmune responseImmune systemImmunologic MonitoringImmunologyInfectionInflammationInstitutesInstructionInvestigationLaboratoriesLungMalignant NeoplasmsMedical centerMentorsMissionMolecularMusNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseaseNatural ImmunityNorris Cotton Cancer CenterPatient CarePhasePilot ProjectsQualifyingResearchResearch InfrastructureResearch PersonnelResearch SupportResourcesServicesSpeedSyndromeTechnologyTransgenic OrganismsUnited States National Institutes of HealthUniversitiesVaccinesVermontbasebench to bedsidecareercatalystcongenicimmunopathologymedical schoolsmicrobialoperationprogramsresponsesuccesssystems researchtranslational approachtumor
项目摘要
Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are
to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and
Translational Immunological Research, and to transition this COBRE Center for Immunological Research
(COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five
years. With the foundation of a long-standing Immunology Program, which has now been substantially
enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative
faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this
expanded investigator base, a Phase III COBRE award will provide the resources to build the needed
infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic
science to translational immunological research. This infrastructure will include the continued mentored
development of our immunlogical faculty, especially those investigators previously supported by COBRE;
expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared
services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung
Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program
with targeting to mentored, collaborative, and/or translational/human systems research. Together with
substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of
investigators, already expanded and matured by the COBRE mechanism, can be further developed to
complete the formation of a sustainable Center for Immunological Research that is grounded in excellent
basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside
application of hypothesis-driven research, and has a regional, if not also national, impact.
基于最初10年奖励的成功,此次COBRE更新申请的最终目标是
完成在达特茅斯建立一个国家认可的分子,细胞,
转化免疫学研究,并将这个COBRE免疫学研究中心
(COBRE-CIR)到一个基于基础设施的,独立的(来自COBRE资金),可持续发展的中心,
年随着一个长期的免疫学计划的基础,现在已经大大
在COBRE的支持下,该提案利用了高度互动的协作核心,
达特茅斯医学院(DMS)和达特茅斯希区柯克医疗中心(DHMC)的教师。与此
为了扩大研究人员的基础,第三阶段COBRE奖将提供资源,以建立所需的
基础设施,以维持COBRE-CIR,进一步发展该计划,并促进跨学科的基本
转化免疫学研究。这一基础设施将包括继续指导
发展我们的免疫学能力,特别是那些以前由COBRE支持的研究人员;
COBRE核心的扩展及其与现有互补核心的完全集成,
DMS/DHMC的服务,特别是诺里斯棉花癌症中心和其他免疫学和“肺”
达特茅斯和佛蒙特大学的生物学”COBREs;以及增强的试点项目计划
以指导、协作和/或翻译/人类系统研究为目标。连同
移民管理局/人权监察委员会的实质性机构承诺,有信心,
调查人员已经通过COBRE机制得到了扩展和成熟,可以进一步发展,
完成一个可持续的免疫学研究中心的形成,该中心以优秀的
基础科学研究,包括一个转化的方法,以促进双向的板凳到床边
这是一个假设驱动的研究的应用,并具有区域性,如果不是也是国家性的影响。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Chimeric Antigen Receptor That Binds to a Conserved Site on MICA.
- DOI:10.4049/immunohorizons.2000041
- 发表时间:2020-10-09
- 期刊:
- 影响因子:0
- 作者:Cook, W James;Choi, Yoonjoo;Sentman, Charles L
- 通讯作者:Sentman, Charles L
Alarmin(g) the innate immune system to invasive fungal infections.
- DOI:10.1016/j.mib.2016.06.002
- 发表时间:2016-08
- 期刊:
- 影响因子:5.4
- 作者:Caffrey AK;Obar JJ
- 通讯作者:Obar JJ
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WILLIAM R GREEN其他文献
WILLIAM R GREEN的其他文献
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{{ truncateString('WILLIAM R GREEN', 18)}}的其他基金
Center for Molecular, Cellular, and Translational Immunology
分子、细胞和转化免疫学中心
- 批准号:
8459371 - 财政年份:2011
- 资助金额:
$ 117.42万 - 项目类别:
Center for Molecular, Cellular, and Translational Immunology
分子、细胞和转化免疫学中心
- 批准号:
8256739 - 财政年份:2011
- 资助金额:
$ 117.42万 - 项目类别:
CENTER FOR MOLECULAR, CELLULAR, AND TRANSLATIONAL IMMUNOLOGY
分子、细胞和翻译免疫学中心
- 批准号:
8364912 - 财政年份:2011
- 资助金额:
$ 117.42万 - 项目类别:
Center for Molecular, Cellular, and Translational Immunology
分子、细胞和转化免疫学中心
- 批准号:
8655174 - 财政年份:2011
- 资助金额:
$ 117.42万 - 项目类别:
Center for Molecular, Cellular, and Translational Immunology
分子、细胞和转化免疫学中心
- 批准号:
8116197 - 财政年份:2011
- 资助金额:
$ 117.42万 - 项目类别:
New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE)
新罕布什尔州 IDeA 生物医学研究卓越网络 (NH-INBRE)
- 批准号:
9901955 - 财政年份:2010
- 资助金额:
$ 117.42万 - 项目类别:
Fundamentals of Bioinformatics sandbox module
生物信息学沙盒模块基础知识
- 批准号:
10557263 - 财政年份:2010
- 资助金额:
$ 117.42万 - 项目类别:
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