CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT

体液和神经因子在脑血流控制中的作用 流动和新陈代谢是有争议的。我们研究了大脑的控制 在正常和压力条件下的血流和新陈代谢。我们的 最初的工作是用高碳酸血症和脱氧葡萄糖模型进行的 压力，但研究可以扩展到其他压力模型，例如， 低氧、低血糖和戒酒。我们的 初步观察表明，来源为肾上腺内侧。 控制脑血流反应的因素 高碳酸血症压力。进一步的研究表明，这些因素之一是 一种三角洲-阿片肽。此外，最近的研究表明，这种反应 高碳酸血症应激的血流量是通过EDRF调节的 (内皮衍生的松弛因子)系统和交感神经 系统。关于三角洲-阿片系统相互作用的进一步细节， EDRF系统，以及交感神经系统中的激活 高碳酸血症患者的脑血情况正在调查中。

The role of humoral and neuronal factors in the control of cerebral blood flow and metabolism is controversial. We studied the control of cerebral blood flow and metabolism under normal and stressful conditions. Our initial work was done with the hypercapnic and deoxyglucose models for stress, but the studies may be extended to other models of stress, e.g., hypoxia hypoglycemia and withdrawal from chronic alcohol consumption. Our initial observations demonstrated that the adrenal medualla was the source of factrs that controlled the response of cerebral blood flow to hypercapnic stress. Further work indicated that one of these factors was a delta-opioid peptide. Also, recent work demonstrated tht the response blood flow to hypercapnic stress is medicated through the EDRF (endothelium derived relaxing factor) system, and the sympathetic nervous system. Further details of the interaction of the delta-opiod system, the EDRF system, and the sympathetic nervous system in the activation of cerebral blood in hypercapnia are under investigation.