NMR STUDIES OF CEREBRAL BLOOD FLOW AND ENERGY METABOLISM

本研究旨在评估一种新的非侵入性诊断方法。 无放射性脑血流量的测定 追踪器。具体地说，我们使用了一种新的19F核磁共振技术来测量 从大脑中清除氟化惰性气体CHF3。我们测试了 比较~(19)F脑血流值的新技术 核磁共振与脑血流值同时测定 放射性微球技术。脑血流值 经~(19)F核磁共振和放射性微球技术测定 相当好，并且对动脉的变化表现出同样的反应 二氧化碳水平。我们的结论是，~(19)F-核磁共振技术给出了一个定量的 脑血流量的测量。 去年，我们使用核磁共振成像技术定位了19F-核磁共振 频谱(以及血流量测量)到一个明确定义的区域 大脑。我们还开始了一系列实验，结合了19F核磁共振 31P测定脑血流量(和氧耗量) 脑能学的核磁共振测定。

This study was undertaken to assess a new method for the non-invasive determination of cerebral blood flow without the use of radioactive tracers. Specifically, we used a new 19F NMR technique to measure the clearance of a fluorinated inert gas, CHF3, from the brain. We tested the new technique by comparing the cerebral blood flow values determined by 19F NMR with cerebral blood flow values determined simultaneously by radioactive microsphere techniques. The cerebral blood flow values determined by 19F NMR and radioactive microsphere techniques agreed reasonably well, and showed the same response to variations in the arterial C02 level. We conclude that the 19F NMR technique gives a quantitative measure of cerebral blood flow. In the last year we used NMR imaging techniques to localize the 19F NMR spectra (and thus the blood flow measurement) to a well defined region of the brain. We also began a series of experiments that combines 19F NMR determination of the cerebral blood flow (and oxygen consumption) with 31P NMR determination of cerebral energetics.