REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

微生物多糖抗原抗体反应的调节

• 批准号: 3768732
• 负责人: P J BAKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3768732
• 关键词: Pseudomonas; antibody formation; bacterial polysaccharides; bactericidal immunity; gram negative bacteria; immunoregulation; leukocyte activation /transformation; suppressor T lymphocyte

Prior treatment with small amounts of inner core-region polysaccharides, from different gram negative bacteria, induced profound T cell mediated suppression of the antibody response. Such suppression is due to an expansion of the pool of suppressor T cells (Ts) activated during the course of a normal antibody response to most bacterial polysaccharide antigens. The minimal structure require to induce suppression is a hexa- saccharide composed of glucose, 2 heptoses and 3 KDO residues. Since this structure is conserved among gram negative bacteria, it may represent an important virulence factor, especially when associated with lipid A molecules, e.g. those present in Pseudomonas species, that are unable to abolish the expression of Ts function.

先用少量内核区多糖处理；