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REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS

REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
微生物多糖抗原抗体反应的调节
批准号：
3768732
负责人：
P J BAKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768732
关键词：
Pseudomonas antibody formation bacterial polysaccharides bactericidal immunity gram negative bacteria immunoregulation leukocyte activation /transformation suppressor T lymphocyte

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中文摘要
翻译
先用少量内核区多糖处理， 从不同的革兰氏阴性菌，诱导深刻的T细胞介导的 抑制抗体反应。 这种抑制是由于 扩增的池抑制T细胞（Ts）激活期间， 对大多数细菌多糖的正常抗体反应过程 抗原 诱导抑制所需的最小结构是六- 由葡萄糖、2个庚糖和3个KDO残基组成的糖。 由于这 结构在革兰氏阴性细菌中是保守的，它可能代表了一种 重要的毒力因子，特别是与脂质A相关时 分子，例如存在于假单胞菌属物种中的那些，其不能 取消Ts函数的表达式。
英文摘要
Prior treatment with small amounts of inner core-region polysaccharides, from different gram negative bacteria, induced profound T cell mediated suppression of the antibody response. Such suppression is due to an expansion of the pool of suppressor T cells (Ts) activated during the course of a normal antibody response to most bacterial polysaccharide antigens. The minimal structure require to induce suppression is a hexa- saccharide composed of glucose, 2 heptoses and 3 KDO residues. Since this structure is conserved among gram negative bacteria, it may represent an important virulence factor, especially when associated with lipid A molecules, e.g. those present in Pseudomonas species, that are unable to abolish the expression of Ts function.
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GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
REGULATION OF THE ANTIBODY RESPONSE TO MICROBIAL POLYSACCHARIDE ANTIGENS
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO MICROBIAL ANTIGENS
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