ANTI-HIV ACTIVITY OF ANTINEOPLASTONS

抗真菌质体是从真菌中分离的肽和氨基酸衍生物。 尿液，并以其对各种癌症的抑制作用而闻名。 这些特工目前正在 HIV感染者 用于治疗他们的淋巴瘤。 过程中 治疗后，注意到HIV抗原水平降低。 它 因此，有兴趣评估这些抗艾滋病毒的效果， 剂. 三种不同的抗真菌质体，苯基钠 苯乙酸钠（PN）和PG的混合物 和PN以1：4的比例进行了针对目标H9中的HIV的测试， U937细胞。 使用的浓度为0.5、0.1、0.05和0.025 微克/毫升。 初步结果表明，PN和PG在0.05和0.1 μ g/ml 抑制HIV复制超过50%，毒性最小。 我们 目前正在评估这些药物的其他浓度， 对HIV复制的影响。

Antineoplastons are peptides and amino acid derivatives isolated from urine and known for their antineoplastic effects in various cancers. These agents are currently being administered to HIV infected individuals for treatment of their lymphomas. In the course of treatment it was noticed that the HIV antigen levels decreased. It was therefore of interest to assess the anti-HIV effects of these agents. Three different antineoplastons, sodium phenyl acetylglutaminate (PG) sodium phenyl acetate (PN) and a mixture of PG and PN in the ratio of 1:4 were tested against HIV in target H9 and U937 cells. The concentrations used were 0.5, 0.1, 0.05, and 0.025 ug/ml. Preliminary results suggest that PN and PG at 0.05 and 0.1 ug/ml inhibit HIV replication by greater than 50% with minimal toxicity. We are at present evaluating other concentrations of these drugs for their effect on HIV replication.