Cardiovascular disease and neurocognition in the elderly

老年人的心血管疾病和神经认知

• 批准号: 6694303
• 负责人: ANGELA L. JEFFERSON
• 金额: $ 3.97万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-16 至 2004-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694303
• 关键词: attention; cardiac output; cardiovascular disorder; clinical research; cognition; cognition disorders; frontal lobe /cortex; functional ability; human old age (65+); human subject; learning; patient oriented research; postdoctoral investigator; psychological aspect of aging; psychomotor function

DESCRIPTION (provided by applicant): Research has demonstrated significant impairments in information processing speed, psychomotor speed and learning among individuals with cardiovascular disease compared to healthy elderly. Such impairments have clinical significance, as cognition is known to influence the functional abilities of the elderly. The purpose of this proposal is to examine the link between cardiac function (i.e., ejection fraction), IADLs, and performance on tests of attention/ vigilance, executive functioning, psychomotor speed, and learning. Impairments of these cognitive functions are hypothesized, as cardiovascular disease is expected to exert greatest influence on cognitive components mediated by frontal-subcortical systems. This study aims to (1) demonstrate an association between impaired cardiac functioning and cognitive impairment, (2) demonstrate that functional activities are compromised in patients with impaired cardiac functioning, and (3) demonstrate that functional impairments among cardiac patients are influenced by cognitive impairments such as executive functioning. A thorough examination of ejection fraction may elucidate the relationship between cardiac compromise and cognition among patients who have not undergone prior cardiac surgery and inform treatment and rehabilitation programs for these patients.

描述（由申请人提供）：研究表明，与健康老年人相比，心血管疾病患者的信息处理速度、心理速度和学习能力明显受损。这种损伤具有临床意义，因为已知认知会影响老年人的功能能力。本提案的目的是检查心脏功能（即，射血分数）、IADL和注意力/警觉性、执行功能、心理速度和学习测试的表现。这些认知功能的损害是假设的，因为预计心血管疾病对额叶皮层下系统介导的认知成分产生最大的影响。本研究旨在（1）证明心脏功能受损与认知障碍之间的关联，（2）证明心脏功能受损患者的功能活动受损，（3）证明心脏病患者的功能障碍受到认知障碍（如执行功能）的影响。射血分数的全面检查可以阐明心脏损害和认知之间的关系，在没有经历过心脏手术的患者，并告知这些患者的治疗和康复计划。