Keystone Symposium on Leukocyte Trafficking

这项提议是为了请求对题为？贩运白细胞？的Keystone研讨会的支持， 由Ulrich von Andrian、Federica Sallusto和Klaus Ley组织，将在科罗拉多州的Keystone举行 从2008年1月13日至18日。在理解细胞和细胞因子方面取得了显著的进展 调控血管内募集、血管外迁移和功能的分子机制 通过使用强大的活体显微镜和Flow可视化细胞与细胞的相互作用来调节免疫细胞 细胞学技术。免疫细胞进出的多肽和脂类调节剂的鉴定 而白细胞黏附分子在原子分辨率下的结构-功能关系导致了 深入了解白细胞亚群分化如何改变迁移能力。早期临床结果 通过像那他珠单抗这样的药物来干扰白细胞的贩运，已经证明不仅 对自身免疫性疾病有显著疗效，但也有可能致命的免疫抑制 人们对此仍然知之甚少。本次会议将汇聚来自各个领域的专家，介绍和 综合我们目前对保护性免疫和病理性免疫调节的机械性见解 并确定如何将这些知识转化为更好、更安全的治疗方法。

This proposal is to request support for a Keystone Symposia meeting entitled ?Leukocyte Trafficking?, organized by Ulrich von Andrian, Federica Sallusto and Klaus Ley, which will be held in Keystone, Colorado from January 13 ? 18, 2008. Remarkable progress has been made in understanding the cellular and molecular mechanisms that govern the intravascular recruitment, extravascular migration and functional regulation of immune cells by visualizing cell-cell interactions using powerful intravital microscopy and flow cytometry techniques. The identification of peptide- and lipid-based regulators of immune cell entry and exit and the structure-function relationship of leukocyte adhesion molecules at atomic resolution have resulted in a refined understanding of how leukocyte subset differentiation modifies migratory ability. Early clinical results with drugs such as natalizumab, which interferes with leukocyte trafficking, have demonstrated not only marked therapeutic efficacy in autoimmune diseases, but also potentially fatal immunosuppression that remains poorly understood. This meeting will bring together experts from a variety of fields to present and synthesize our current mechanistic insights into the regulation of protective and pathological immune responses and to determine how this knowledge can be translated to better and safer therapies.