Keystone Symposium on Leukocyte Trafficking

白细胞贩运基石研讨会

• 批准号: 7328570
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.4万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7328570
• 关键词: Autoimmune Diseases; Biological Response Modifiers; Cell Communication; Cells; Clinical; Colorado; Flow Cytometry; Immune; Immune response; Immunosuppression; Knowledge; Leukocyte Trafficking; Leukocyte-Adhesion Receptors; Leukocytes; Lipids; Molecular; Peptides; Pharmaceutical Preparations; Regulation; Resolution; Structure-Activity Relationship; Techniques; Therapeutic immunosuppression; Translating; Treatment Efficacy; base; insight; intravital microscopy; migration; natalizumab; symposium

This proposal is to request support for a Keystone Symposia meeting entitled ?Leukocyte Trafficking?, organized by Ulrich von Andrian, Federica Sallusto and Klaus Ley, which will be held in Keystone, Colorado from January 13 ? 18, 2008. Remarkable progress has been made in understanding the cellular and molecular mechanisms that govern the intravascular recruitment, extravascular migration and functional regulation of immune cells by visualizing cell-cell interactions using powerful intravital microscopy and flow cytometry techniques. The identification of peptide- and lipid-based regulators of immune cell entry and exit and the structure-function relationship of leukocyte adhesion molecules at atomic resolution have resulted in a refined understanding of how leukocyte subset differentiation modifies migratory ability. Early clinical results with drugs such as natalizumab, which interferes with leukocyte trafficking, have demonstrated not only marked therapeutic efficacy in autoimmune diseases, but also potentially fatal immunosuppression that remains poorly understood. This meeting will bring together experts from a variety of fields to present and synthesize our current mechanistic insights into the regulation of protective and pathological immune responses and to determine how this knowledge can be translated to better and safer therapies.

这一建议是要求支持一个基石专题讨论会会议，题为？白细胞运输？， 由Ulrich von Andrian，Federica Sallusto和Klaus Ley组织，将在科罗拉多的Keystone举行 从1月13日起？2008年18日。在理解细胞和 控制血管内募集、血管外迁移和功能性 通过使用强大的活体显微镜和流式细胞术可视化细胞-细胞相互作用来调节免疫细胞 细胞计数技术。基于肽和脂质的免疫细胞进出调节剂的鉴定 以及原子分辨率下白细胞粘附分子的结构-功能关系， 对白细胞亚群分化如何改变迁移能力的深入理解。早期临床结果 与干扰白细胞运输的那他珠单抗（natalizumab）等药物的接触，不仅证明了 在自身免疫性疾病中具有显著的治疗效果，但也可能是致命的免疫抑制， 仍然知之甚少。这次会议将汇集来自各个领域的专家， 综合我们目前对保护性和病理性免疫调节机制的认识， 反应，并确定如何将这些知识转化为更好，更安全的治疗方法。