Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

• 批准号: 9143419
• 负责人: WALTER ROGAN
• 金额: $ 43.26万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9143419
• 关键词: Breast; Data Analyses; Estradiol; Estrogens; Genistein; Gonadal Steroid Hormones; Gonadotropins; Growth and Development function; Infant; Isoflavones; Longitudinal Studies; Methods; Modeling; Organ; Ovary; Reporting; Serum; Soybeans; Tissues; Urethra; Uterus; Vagina; Validation; daidzein; feeding; follow-up; soy

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.

染料木素和大豆黄酮是大豆中的雌激素异黄酮。虽然它们的效力远不如雌二醇，但食用大豆配方奶粉的婴儿的血清浓度比雌二醇高4个数量级。我们对9个月大的婴儿进行了纵向研究，详细观察了他们的雌激素反应组织、性激素和促性腺激素的生长发育情况。我们于2014年5月完成随访，并开始数据分析。此外，我们今年报道了一种评估婴儿雌激素暴露的细胞学方法的验证。

项目成果

Perchlorate exposure and dose estimates in infants.

婴儿高氯酸盐暴露和剂量估计。

• DOI: 10.1021/es103160j
• 发表时间: 2011
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: Valentín-Blasini,Liza;Blount,BenjaminC;Otero-Santos,Samaret;Cao,Yang;Bernbaum,JudyC;Rogan,WalterJ
• 通讯作者: Rogan,WalterJ

Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study.

• DOI: 10.1289/ehp.1306925
• 发表时间: 2014-05
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Wang Y;Rogan WJ;Chen PC;Lien GW;Chen HY;Tseng YC;Longnecker MP;Wang SL
• 通讯作者: Wang SL

Triclosan and prescription antibiotic exposures and enterolactone production in adults.

• DOI: 10.1016/j.envres.2015.06.017
• 发表时间: 2015-10
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Adgent MA;Rogan WJ
• 通讯作者: Rogan WJ

Maternal obesity and the risk of infant death in the United States.

• DOI: 10.1097/ede.0b013e3181878645
• 发表时间: 2009-01
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Chen A;Feresu SA;Fernandez C;Rogan WJ
• 通讯作者: Rogan WJ