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Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

基本信息

批准号：
7734431
负责人：
WALTER ROGAN
金额：
$ 43.14万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

项目摘要

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they much less potent as estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. Anatomic, sonographic, and other biochemical evidence of estrogen exposure has not been looked for in infants fed soy. Whether such widely used products do or do not have clinically detectable estrogenic activity in infants, the group with the highest exposure per kilo, is important clinically; in addition, it may be a crucial test of the ability of laboratory measures of estrogenicity to predict actual endocrine response in humans. We have done the field work for pilot studies to examine the natural history of estrogen responsive physiology in the newborn, and have used the results to develop a longitudinal study of the possible estrogenic effects of soy formula on infants. Using samples from this project, we are collaborating with the Centers for Disease Control to see if perchlorate, a contaminant of the US water supply, lowers thyroid hormone levels in infants as it does in adult females. We are currently recontacting families who told us to ask them before analyzing their childs samples for substances other than those in the original study plan. We will use the samples from those who give their consent now, plus those who originally gave consent for general use of their samples, to measure concentrations of perchlorate, iodine, and thiocyanate in infants for whom we have already measured thyroid hormone. We are also using samples from this study to examine the hormonal basis of the relative anesthesia of breast fed infants.

金雀异黄酮和大豆黄酮是大豆中发现的雌激素异黄酮。尽管它们的效力不如雌二醇，但喂养大豆配方奶粉的婴儿的血清浓度比雌二醇高出 4 个数量级。尚未在食用大豆的婴儿中寻找雌激素暴露的解剖学、超声检查和其他生化证据。这些广泛使用的产品是否对婴儿（每公斤暴露量最高的群体）具有临床可检测的雌激素活性，在临床上很重要；此外，这可能是对雌激素性实验室测量预测人类实际内分泌反应能力的重要测试。我们已经完成了试点研究的实地工作，以检查新生儿雌激素反应生理学的自然历史，并利用这些结果开展了一项关于大豆配方奶粉对婴儿可能的雌激素影响的纵向研究。我们正在与疾病控制中心合作，利用该项目的样本来观察美国供水污染物高氯酸盐是否会像成年女性一样降低婴儿的甲状腺激素水平。我们目前正在重新联系一些家庭，他们告诉我们在分析孩子样本中是否存在原始研究计划中以外的物质之前先询问他们。我们将使用现在同意的样本，加上最初同意一般使用其样本的样本，来测量我们已经测量过甲状腺激素的婴儿的高氯酸盐、碘和硫氰酸盐的浓度。我们还使用这项研究的样本来检查母乳喂养婴儿相对麻醉的激素基础。