NEUROENDOCRINE FACTORS IN ADOLESCENT OBESITY

青少年肥胖的神经内分泌因素

• 批准号: 7374760
• 负责人: ANNE KLIBANSKI
• 金额: $ 4.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374760
• 关键词: NEUROENDOCRINE; FACTORS; ADOLESCENT; OBESITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH), and insulin, which have not been examined in the adolescent age group. Ghrelin, a hormone produced mainly in the stomach, increases appetite and causes GH secretion. This study will compare the change in secretion of ghrelin and GH in overweight and normal weight adolescent girls. Understanding obesity-related changes in ghrelin and GH and their relationship to body composition, insulin resistance, and appetite will help in the development of strategies to reduce complications of obesity.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。肥胖是一种流行病，其发病年龄比以往任何时候都年轻。肥胖与多种激素分泌模式的变化有关，包括生长素释放肽、生长激素 (GH) 和胰岛素，但尚未在青少年年龄组中进行研究。生长素释放肽是一种主要在胃中产生的激素，可增加食欲并引起 GH 分泌。本研究将比较超重和正常体重青春期女孩的生长素释放肽和生长激素分泌变化。了解与肥胖相关的生长素释放肽和生长激素的变化及其与身体成分、胰岛素抵抗和食欲的关系将有助于制定减少肥胖并发症的策略。