Keystone Symposium on Chemokines and Chemokine Receptors

趋化因子和趋化因子受体 Keystone 研讨会

• 批准号: 7324033
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7324033
• 关键词: Cells; Clinical assessments; Colorado; Complex; Condition; Development; Elements; Family; Human Pathology; Image Analysis; Immunity; Leukocytes; Lymphoid Tissue; Mediator of activation protein; Pathology; Positioning Attribute; Regulation; Scientist; System; Therapeutic; Translations; abstracting; cell motility; chemokine; chemokine receptor; innovation; leukocyte activation; novel diagnostics; symposium; tool; trafficking

ABSTRACT This proposal is to request support for a Keystone Symposia meeting entitled ¿Chemokines and Chemokine Receptors¿, which will be held in Keystone, Colorado from January 13 ¿ 18, 2008. Cell migration is a key element for the ontogenesis of lymphoid tissues under homeostatic and pathological conditions, for the patrolling of body compartments by leukocytes, and for the activation and orientation of innate and adaptive immunity. Chemokines are a major component of the trafficking, positioning and functional regulation of leukocytes and nonhematopoietic cells in normal conditions and in diverse pathologies. Structural analysis and imaging approaches have resulted in a better understanding of the action of this complex family of mediators. Chemokines are a prime target for the development of innovative therapeutic strategies, some of which are beginning to undergo clinical assessment. This meeting will bring together scientists and clinicians with different expertise to summarize the current understanding of the chemokine system and its involvement in human pathology, focusing on prospects and challenges for translation into new diagnostic and therapeutic tools.

摘要 该提案要求支持一个名为“趋化因子和趋化因子”的Keystone研讨会会议， 接待员，这将是在基石，科罗拉多从2008年1月13日至18日举行。细胞迁移是一个关键 在稳态和病理条件下淋巴组织个体发生的元素， 白细胞巡逻身体隔室，以及先天和适应性的激活和定位 免疫力趋化因子是一个主要的组成部分，运输，定位和功能调节， 白细胞和非造血细胞。结构分析 和成像的方法已经导致了更好地了解这个复杂的家庭的行动， 调解员趋化因子是开发创新治疗策略的主要目标，其中一些 目前正在进行临床评估。这次会议将汇集科学家和临床医生 总结目前对趋化因子系统及其参与的理解， 在人类病理学，重点是转化为新的诊断和治疗的前景和挑战， 工具.