MPM STUDY OF ANIMAL SYNOVIUM TO OBTAIN INSIGHT INTO AFFECTS OF ARTHRITIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 退行性关节疾病是成年人身体残疾的最常见原因之一。早期诊断、退变阶段的表征和监测关节面对治疗的反应是至关重要的。如今，关节疾病检测仅限于通过关节镜检查、X射线照相术、CAT、MRI和超声对关节表面进行可视化。这些技术中没有一种给出优于100微米的分辨率。使用MPM（随着内窥镜的发展）对关节软骨/滑膜结构进行成像可能会对诊断能力和准确性提供显着的益处。 实现最终目标的第一步是使用MPM研究动物关节并识别疾病的迹象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Degenerative joint disease is one of the most frequent causes of physical disability among adults. Early diagnosis, characterization of the stage of degeneration, and monitoring the response of articular surfaces to treatment is essential. Today, joint disease detection is limited to visualization of joint surfaces by arthroscopy, radiography, CAT, MRI and ultrasound. None of these techniques gives a resolution better that 100 micron. Using MPM (with the development of a endoscope) for imaging articular cartilage/synovial structure may provide significant benefit to diagnosing ability and accuracy. The first step toward the ultimate goal is to study animal joints using MPM and discern signs of disease.