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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
7965831
负责人：
Heidi Kong
金额：
$1.05万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7965831
关键词：
BiopsyClinicalCutaneousCytochrome P450DataDiureticsDoxycyclineEnsureGene ExpressionGene Expression ProfilingGenotypeGoalsLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityReactionRecommendationRoleSkinSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteerhuman subjecttranslational approachultraviolet

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中文摘要
翻译
在2009财年，我们开始分析从服用多西环素前后对受试者进行光测试获得的皮肤光毒性皮肤活检获得的微阵列数据，以获得多西环素引起皮肤光毒性的临床信息。对数据进行了评估，以确保微阵列芯片产生足够的数据。目前的分析将评估紫外线照射下的皮肤活检与对照组以及多西环素诱导的光毒性皮肤与对照组相比是否存在差异。
英文摘要
In fiscal year 2009, we began analysis of the microarray data obtained from skin biopsies of skin phototoxicity obtained from phototesting of human subjects before and after doxycycline ingestiont to obtain clinical information on doxycycline-induced cutaneous phototoxicity. The data were evaluated to ensure that the microarray chips yielded sufficient data. The current analyses will evaluate whether there were differences in those skin biopsies from ultraviolet light-exposed skin compared to controls and doxycycline-induced phototoxic skin compared to controls.
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