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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号:
7965831
负责人:
Heidi Kong
金额:
$1.05万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
翻译
在2009财政年度,我们开始分析从人体受试者摄入强力霉素前后的皮肤光毒性的皮肤活检中获得的微阵列数据,以获得强力霉素诱导的皮肤光毒性的临床信息。对数据进行评估,以确保微阵列芯片产生足够的数据。目前的分析将评估紫外线照射皮肤的皮肤活检与对照组和多西环素诱导的光毒性皮肤活检与对照组是否存在差异。
英文摘要
In fiscal year 2009, we began analysis of the microarray data obtained from skin biopsies of skin phototoxicity obtained from phototesting of human subjects before and after doxycycline ingestiont to obtain clinical information on doxycycline-induced cutaneous phototoxicity. The data were evaluated to ensure that the microarray chips yielded sufficient data. The current analyses will evaluate whether there were differences in those skin biopsies from ultraviolet light-exposed skin compared to controls and doxycycline-induced phototoxic skin compared to controls.
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