Gene Expression Profiling and Clinical Characterization of Phototoxicity

光毒性的基因表达谱和临床特征

• 批准号: 7965831
• 负责人: Heidi Kong
• 金额: $ 1.05万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7965831
• 关键词: Biopsy; Clinical; Cutaneous; Cytochrome P450; Data; Diuretics; Doxycycline; Ensure; Gene Expression; Gene Expression Profiling; Genotype; Goals; Light; Microarray Analysis; Non-Steroidal Anti-Inflammatory Agents; Pathway interactions; Pharmaceutical Preparations; Phototoxicity; Reaction; Recommendation; Role; Skin; Sunscreening Agents; Testing; Ultraviolet Rays; Visible Radiation; Voriconazole; antimicrobial; healthy volunteer; human subject; translational approach; ultraviolet

In fiscal year 2009, we began analysis of the microarray data obtained from skin biopsies of skin phototoxicity obtained from phototesting of human subjects before and after doxycycline ingestiont to obtain clinical information on doxycycline-induced cutaneous phototoxicity. The data were evaluated to ensure that the microarray chips yielded sufficient data. The current analyses will evaluate whether there were differences in those skin biopsies from ultraviolet light-exposed skin compared to controls and doxycycline-induced phototoxic skin compared to controls.

在2009财政年度，我们开始分析从皮肤中获得的微阵列数据， 从人类受试者光试验前后获得的皮肤光毒性活组织检查 多西环素摄入以获得多西环素诱导的皮肤炎的临床信息 光毒性对数据进行评估，以确保微阵列芯片产生足够的 数据目前的分析将评估这些皮肤活检是否存在差异 与对照组相比， 与对照组相比，