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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
7965831
负责人：
Heidi Kong
金额：
$1.05万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7965831
关键词：
BiopsyClinicalCutaneousCytochrome P450DataDiureticsDoxycyclineEnsureGene ExpressionGene Expression ProfilingGenotypeGoalsLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityReactionRecommendationRoleSkinSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteerhuman subjecttranslational approachultraviolet

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英文摘要
In fiscal year 2009, we began analysis of the microarray data obtained from skin biopsies of skin phototoxicity obtained from phototesting of human subjects before and after doxycycline ingestiont to obtain clinical information on doxycycline-induced cutaneous phototoxicity. The data were evaluated to ensure that the microarray chips yielded sufficient data. The current analyses will evaluate whether there were differences in those skin biopsies from ultraviolet light-exposed skin compared to controls and doxycycline-induced phototoxic skin compared to controls.
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Gene Expression Profiling and Clinical Characterization of Phototoxicity
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