Gene Expression Profiling and Clinical Characterization of Phototoxicity

2010年，该方案进行了修订，允许我们用强力霉素治疗一部分返回的健康志愿者，以获得额外的活组织检查。2011年，我们完成了对新增健康志愿者的治疗。2012年，我们完成了对接受强力霉素治疗的健康志愿者的额外活检的免疫组织化学染色分析。在2013财年，我们调查了前几年参与研究的健康志愿者的血清强力霉素水平。在2017财政年度，该协议进行了修订，允许对紫外线照射后的皮肤样本进行额外的调查，但调查结果尚无定论。基于用强力霉素治疗健康志愿者的临床研究经验，随后制定了一项方案来分析与强力霉素摄入相关的人类微生物组改变。该研究的结果于2022财年公布。

In 2010, the protocol was amended to allow us to treat a subset of returning healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of the additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of the additional biopsies obtained from healthy volunteers treated with doxycycline. In fiscal year 2013, we investigated the serum levels of doxycycline from the healthy volunteers who participated in the study in previous years. In fiscal year 2017, the protocol was amended to allow additional investigation of skin samples post-UV exposure which were inconclusive. Based upon the clinical research experience from treating healthy volunteers with doxycycline, a protocol was subsequently developed to analyze the human microbiome alterations associated with doxycycline ingestion. The findings of that study were published in fiscal year 2022.