Effects of systemic and topical perturbations on human microbes

全身和局部扰动对人类微生物的影响

• 批准号: 9556630
• 负责人: Heidi Kong
• 金额: $ 74.94万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9556630
• 关键词: Communities; Disease; Genome; Goals; Health; Human; Inflammatory; Intervention; Malignant Neoplasms; Microbe; Modality; Patient Recruitments; Patients; Protocols documentation; Role; Skin; Technology; healthy volunteer; individual patient; interest; microbial community; microbial host; microbiome; oncology

The goal of this project is to implement systematically different skin-directed and systemic modalities in healthy volunteers and patients to explore how human microbial communities are altered. In addition to identifying changes in host microbial communities, we have been working to develop ways to study the potential effects of microbiome alterations on host health and disease. In the last fiscal year, we have continued to recruit patients and healthy volunteers to participate and to provide biospecimens. Additionally, we are working with collaborators who have interventional protocols to investigate the composition of host microbial communities prior to and after implementation of systemic or topical interventions.

该项目的目标是在健康志愿者和患者中系统地实施不同的皮肤定向和系统模式，以探索人类微生物群落如何改变。除了确定宿主微生物群落的变化外，我们一直在努力开发研究微生物组改变对宿主健康和疾病的潜在影响的方法。在上一个财政年度，我们继续招募患者和健康志愿者参与并提供生物标本。此外，我们正在与具有干预方案的合作者合作，以调查在实施系统或局部干预之前和之后宿主微生物群落的组成。