Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients

我们扩大了我们的工作范围，将真菌作为健康成人多个皮肤部位的人体皮肤微生物组的一部分，并继续研究皮肤微生物组波动与皮肤疾病的相关性。在2013财政年度，我们完成了分析，并发表了一篇关于健康成年人皮肤真菌微生物组的手稿。我们继续研究原发性免疫缺陷伴皮炎（高IgE综合征和Wiskott-Aldrich综合征）患者的皮肤微生物组，此外还对先前招募的受试者进行了随访采样。该项目的测序由美国国立卫生研究院路线图项目，人类微生物组项目资助。我们一直在继续分析上一财年特应性皮炎、高IgE综合征和Wiskott-Aldrich综合征患者的微生物组数据。

We have expanded our work by including studies of fungi as part of the human skin microbiome of multiple skin sites in healthy adults as well as continued to investigate the relevance of the skin microbiome fluctuations to skin diseases. In fiscal year 2013, we completed analysis and published a manuscript about the fungal skin microbiome healthy adults. We continue to study the skin microbiome in patients primary immunodeficiencies with dermatitis (hyper-IgE syndrome and Wiskott-Aldrich syndrome), in addition to follow-up sampling visits from previously enrolled subjects. The sequencing for this project is funded by the National Institutes of Health Roadmap Project, The Human Microbiome Project. We have been continuing to analyze the microbiome data from patients with atopic dermatitis, hyper-IgE syndrome and Wiskott-Aldrich syndrome in the last fiscal year.