Investigating the microbiome in persons living with HIV

调查艾滋病毒感染者的微生物组

• 批准号: 10710341
• 负责人: Heidi Kong
• 金额: $ 26.38万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710341
• 关键词: Clinical; Collaborations; Complex; Data Analyses; Disease; Goals; HIV; HIV Infections; Human Microbiome; Immune System Diseases; Immune system; Immunity; Individual; Inflammation; Inflammatory; Monitor; Opportunistic Infections; Persons; Predisposition; Research Proposals; Skin; Viral Load result; antiretroviral therapy; comorbidity; host microbiota; microbial; microbiome; microbiome sequencing

We have established a collaboration to clinically evaluate and collect biospecimens from persons living with HIV. In a cross-sectional manner, we have collected biospecimens from individuals prior to the initiation of antiretroviral therapy as well as individuals on antiretroviral therapy. We have performed microbiome sequencing of biospecimens and are analyzing data from individuals who have initiated antiretroviral therapy in order to monitor the human microbiome as the immune system is restored and as viral load is controlled.

我们建立了一个协作机制，对艾滋病毒感染者进行临床评估并收集生物标本。在一个横截面的方式，我们已经收集了生物标本，从个人开始抗逆转录病毒治疗之前，以及个人的抗逆转录病毒治疗。我们已经对生物标本进行了微生物组测序，并正在分析来自已开始抗逆转录病毒治疗的个人的数据，以便在免疫系统恢复和病毒载量得到控制时监测人体微生物组。