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Botulinum Toxin for Painful Cutaneous Leiomyomas

Botulinum Toxin for Painful Cutaneous Leiomyomas
肉毒杆菌毒素治疗疼痛性皮肤平滑肌瘤
批准号：
8763383
负责人：
Heidi Kong
金额：
$6.55万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8763383
关键词：
AcetylcholineAcetylcholinesteraseAdverse effectsBotulinum ToxinsCalcitonin Gene-Related PeptideCancer PatientClinicalClinical ProtocolsCutaneous LeiomyomaDouble-Blind MethodEnrollmentEtiologyHair follicle structureHereditary Leiomyomatosis and Renal Cell CancerInjection of therapeutic agentLeiomyomaLesionMediatingMusMuscleMuscle ContractionNerveNerve FibersNeural ConductionNeuropeptidesPainPain NaturePathway interactionsPatientsPilot ProjectsPlacebo ControlProtocols documentationQuality-of-Life AssessmentReportingResearch DesignRoleStaining methodStainsStudy SubjectSymptomsTravelUnited States National Institutes of HealthVisitalpha-adrenergic receptorbasediarieshair erector musclenerve supplypressureresponse

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中文摘要
翻译
我们对肉毒毒素a治疗疼痛性皮肤平滑肌瘤的初步研究将评估注射后患者是否能缓解疼痛。考虑到疼痛通常是主观的，我们设计了一个安慰剂控制和双盲的研究方式。在研究期间，受试者将在研究访问时使用标准化疼痛评分量表和疼痛日记对疼痛进行评分。受试者还将完成生活质量评估。由于这种情况的罕见性和患者难以前往NIH临床中心参加方案，累积缓慢。在2013财政年度，我们为临床方案招募了更多的受试者。
英文摘要
Our pilot study of botulinum toxin-A for painful skin leiomyomas will evaluate whether patients receive pain relief after injection. Given the often subjective nature of pain, we have designed the study in a placebo-controlled and double-blinded fashion. For the duration of the study, subjects will rate their pain using standardized pain scoring scales at study visits and through a pain diary. Subjects will also complete quality of life assessments. Due to the rarity of this condition and difficulty for patients to travel to the NIH Clinical Center for protocol participation, accrual has been slow. In fiscal year 2013, we enrolled additional subjects to the clinical protocol.
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Effects of systemic and topical perturbations on human microbes
Botulinum Toxin for Painful Cutaneous Leiomyomas
Gene Expression Profiling and Clinical Characterization of Phototoxicity
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
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