Effects of systemic and topical perturbations on human microbes

该项目的目标是在健康志愿者和患者中系统地实施不同的皮肤定向和系统模式，以探索人类微生物群落如何改变。除了确定宿主微生物群落的变化外，我们一直在努力开发研究微生物组改变对宿主健康和疾病的潜在影响的方法。在上一个财政年度，我们继续研究来自特定疾病患者和健康志愿者的样本，以了解与干预措施相关的可能的微生物组变化。此外，我们正在与具有干预方案的合作者合作，以调查在实施系统或局部干预之前和之后宿主微生物群落的组成。这些研究包括肿瘤患者的免疫治疗研究和人类受试者的抗菌剂研究。

The goal of this project is to implement systematically different skin-directed and systemic modalities in healthy volunteers and patients to explore how human microbial communities are altered. In addition to identifying changes in host microbial communities, we have been working to develop ways to study the potential effects of microbiome alterations on host health and disease. In the last fiscal year, we have continued to study samples from patients with specific disorders and healthy volunteers for possible microbiome changes related to interventions. Additionally, we are working with collaborators who have interventional protocols to investigate the composition of host microbial communities prior to and after implementation of systemic or topical interventions. These include studies of immunotherapy treatments in oncology patients and antimicrobials in human subjects.