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Cutaneous Adverse Drug Reactions

Cutaneous Adverse Drug Reactions
皮肤药物不良反应
批准号：
7965853
负责人：
Heidi Kong
金额：
$4.21万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7965853
关键词：
Adverse effectsAppearanceBAY 54-9085BiopsyClassificationClinicClinicalClinical TrialsCollaborationsConsultCutaneousDataDermatologicDermatologistDermatologyDiagnosisDoseDrug toxicityEvaluationGoalsHandKnowledgeLifeMediatingMedicalNational Cancer InstituteOncologistPainPalmar-plantar erythrodysesthesia syndromePathogenesisPatientsPharmaceutical PreparationsPhotographyProtocols documentationPublishingReactionRecording of previous eventsResearchRisk FactorsSkinTherapeuticTimeUnited States National Institutes of Healthbaseexperiencefootimprovedmedical specialtiesnoveloncologyresearch clinical testing

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In fiscal year 2009, we published the data on hand-foot skin reaction related to sorafenib therapy from three NCI intramural trials to better understand the potential risk factors and possible pathogenesis of this painful treatment-limiting cutaneous adverse effect. This research required multi-specialty collaboration among dermatologists, oncologists, pharmacologists and statisticians. Patients on other investigational therapeutics are being systematically evaluated dermatologically at baseline and while on treatment. In addition to thorough clinical evaluations, subjects may undergo skin biopsies and medical photography.
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