Gene Expression Profiling and Clinical Characterization of Phototoxicity

光毒性的基因表达谱和临床特征

• 批准号: 8552888
• 负责人: Heidi Kong
• 金额: $ 3.94万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552888
• 关键词: Biopsy; Clinical; Cutaneous; Cytochrome P450; Data; Diuretics; Doxycycline; Gene Expression; Gene Expression Profiling; Genotype; Goals; Light; Microarray Analysis; Non-Steroidal Anti-Inflammatory Agents; Pathway interactions; Pharmaceutical Preparations; Phototoxicity; Protocols documentation; Reaction; Recommendation; Role; Serum; Skin; Staining method; Stains; Sunscreening Agents; Testing; Ultraviolet Rays; Visible Radiation; Voriconazole; antimicrobial; follow-up; healthy volunteer; translational approach; ultraviolet

In fiscal year 2012, we continued to follow up with the results obtained with our microarray data. In 2010, the protocol was amended to allow us to treat healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of additional biopsies obtained from healthy volunteers treated with doxycycline. We also sent stored serum from the initial healthy volunteers to evaluate for doxycycline serum levels, which have recently been completed.

在2012财年，我们继续跟进利用我们的微阵列数据获得的结果。2010年，对方案进行了修改，允许我们用多西环素治疗健康志愿者，以获得更多的活检。2011年，我们完成了对更多健康志愿者的治疗。2012年，我们完成了对接受多西环素治疗的健康志愿者的额外活检的免疫组织化学染色分析。我们还从最初的健康志愿者那里发送了储存的血清，以评估最近完成的多西环素血清水平。