Kinetochore Interaction with Centromere Chromatin in human cells
Kinetochore Interaction with Centromere Chromatin in human cells
批准号:
7966221
负责人:
YAMINI P DALAL
金额:
$21.18万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
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英文摘要
We have immunopurified CENPA containing chromatin complexes from normal (HeLa) and 4 colorectal cancer cell lines. We find that there appear to be two fractions of CENPA in the genome and that CENPC may be differentially localized in these two fractions. Experiments are currently underway to precisely pinpoint using atomic force microscopy how CENPC is bound to CENPA. We have created multiple CENPA constructs with "swapped" domains to further dissect precisely which part of the CENPA protein is essential for direct or indirect interaction with the CENPC and other core kinetochore proteins in human cells.
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Analysis of centromere identity and structure in human cells
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Analysis of centromere identity and structure in human cells
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Kinetochore Interaction with Centromere Chromatin in human cells
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批准号:8157701
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Genome wide profiling of histone variants in colorectal cancer cells
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资助金额:$49.99万
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Biomechanical properties of chromatin in cancer and normal cells
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Genome wide profiling of histone variants in tumors
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Analysis of centromere identity and structure in human cells
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Role of histone variants in aging and cancer
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Genome wide profiling of histone variants in colorectal cancer cells
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资助金额:$52.96万
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Analysis of centromere identity and structure in human cells
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批准号:8763399
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财政年份:--
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Role of histone variants in aging and cancer
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财政年份:--
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Formation of Centromeres in vivo
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批准号:10926164
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资助金额:$20.16万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Genome wide profiling of histone variants in colorectal cancer cells
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批准号:8157698
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项目类别:
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资助金额:$47.43万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Analysis of centromere identity and structure in human cells
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资助金额:$29.99万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Kinetochore Interaction with Centromere Chromatin in human cells
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批准号:8553042
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项目类别:
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资助金额:$20.37万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Analysis of centromere identity and structure in human cells
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批准号:8938010
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资助金额:$37.93万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Analysis of centromere identity and structure in human cells
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批准号:9153820
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资助金额:$43.86万
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财政年份:--
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负责人:YAMINI P DALAL
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依托单位:
Formation of Centromeres in vivo
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批准号:10486792
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项目类别:
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资助金额:$35.9万
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财政年份:--
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负责人:YAMINI P DALAL
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