CARDIOVASCULAR DISEASE AND MICROVASCULAR DYSFUNCTION IN FAT-FED RHESUS MONKEYS

脂肪喂养恒河猴的心血管疾病和微血管功能障碍

• 批准号: 8173225
• 负责人: KEVIN L GROVE
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173225
• 关键词: Accounting; Blood capillaries; Cardiovascular Diseases; Cardiovascular system; Clinical; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Detection; Diabetes Mellitus; Diabetic Angiopathies; Diet; Disease; Early Diagnosis; Early identification; Fatty acid glycerol esters; Functional disorder; Funding; Grant; Hyperglycemia; Institution; Insulin Resistance; Macaca mulatta; Methods; Morbidity - disease rate; Obesity; Organ; Pathogenesis; Patients; Perfusion; Peripheral; Peripheral Vascular Diseases; Protocols documentation; Quality of life; Research; Research Personnel; Resources; Source; Techniques; Therapeutic Intervention; Tissues; Ultrasonography; United States National Institutes of Health; capillary; feeding; high risk; mortality; nonhuman primate; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular complications account for the vast majority of the mortality and morbidity associated with diabetes (DM). These complications can be broadly categorized as macrovascular and microvascular. Microvascular complications of DM often have devastating effects on the quality of life and survival for patients with diabetes. It is now well recognized that many of microvascular complications are directly related to the degree of hyperglycemia and insulin resistance. However, our understanding of the pathogenesis and appropriate treatment of these disorders is rudimentary. Early detection of microvascular abnormalities will be useful for identifying patients with DM, insulin resistance, or obesity who are at high risk for developing major end-organ complications and who could benefit from therapeutic intervention. A method for routinely assessing microvascular flow reserve could also be useful for early identification of patients with peripheral vascular disease who are candidates for revascularization or other treatments, similar to protocols that are currently employed for the detection of coronary artery disease. Despite the great clinical need, a reliable, non-invasive method capable of assessing perfusion of peripheral tissues at the microvascular or capillary level in patients is currently not available. The overall aim of this proposal is to characterize the microvascular complications are associated with diet induced obesity/insulin resistance in the nonhuman primate (NHP) and that these abnormal responses can be assessed by contrast-enhanced ultrasound (CEU). These studies are using a combination of noninvasive techniques to characterize the level of cardiovascular disease in rhesus macaques chronically consuming a high fat diet.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心血管并发症占与糖尿病（DM）相关的绝大多数死亡率和发病率。这些并发症可以大致归类为大血管和微血管。 DM的微血管并发症通常会对糖尿病患者的生活质量和生存质量产生毁灭性影响。现在已经众所周知，许多微血管并发症与高血糖和胰岛素抵抗的程度直接相关。但是，我们对这些疾病的发病机理和适当治疗的理解是基本的。 及早检测微血管异常将有助于识别患有DM，胰岛素抵抗或肥胖症患者的患者，这些患者患有高风险患有主要的最终器官并发症，并且可以从治疗性干预中受益。一种常规评估微血管流量储备的方法也可能有助于早期鉴定出是血运重建或其他治疗方法的外周血管疾病患者，类似于目前用于检测冠状动脉疾病的方案。尽管临床需求很大，但目前尚无一种可靠的，无创的方法，能够评估患者微血管或毛细血管水平上周围组织的灌注。该提案的总体目的是表征微血管并发症与非人类灵长类动物（NHP）中饮食诱导的肥胖/胰岛素抵抗有关，并且可以通过对比增强超声（CEU）评估这些异常反应。这些研究使用了非侵入性技术的组合来表征恒河猕猴的心血管疾病水平，从而长期消耗了高脂肪饮食。